Results 161 to 170 of about 9,504,189 (270)

test

, 2000
test
core  

Study on the influence of TBM disc cutter on the penetration of extremely hard rock in Zijing Tunnel

Electronic Journal of Structural Engineering
The reasonable setting of TBM disc cutter penetration depth is crucial for its rock-breaking efficiency in extremely hard rock geology. In the construction section of the Dujiangyan to Mount Siguniang Zijing Tunnel project, which encountered extremely ...
Chao Gao, Yufeng Huang, Qi Geng, Xiaowu Han, Huijian Zhang, Rucheng Hu, Fei Liu   +6 more
doaj  

Diagnostic evidence in suspected discogenic low back pain: a pain-source attribution perspective. [PDF]

Front Med (Lausanne)
Zhang R, Liang Y, Zhang C, Liu Y, Hong Y.   +4 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

PHGDH-Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration. [PDF]

Adv Sci (Weinh)
Xu HW, Chang SJ, Liu XW, Zhang SB, Wang YJ, Wang SJ.   +5 more
europepmc   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

A machine learning model integrating radiomics and clinical factors to predict recurrence risk after rehabilitation in lumbar disc herniation. [PDF]

Medicine (Baltimore)
Qi Y, Feng Y, Xing X, Wang Z, Yang Y, Zhang L, Yu W.   +6 more
europepmc   +1 more source

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

Development of a multiplex detection system for toxic <i>Amanita</i> species based on isothermal recombinase polymerase amplification and CRISPR/Cas12b technology. [PDF]

Front Mol Biosci
Li H, Ying X, Luo Z, Lu C, Zhang P.
europepmc   +1 more source