The modified Hodge test is a useful tool for ruling out Klebsiella pneumoniae carbapenemase [PDF]
Clinics, 2012 OBJECTIVE: Enterobacteriaceae bacteria harboring Klebsiella pneumoniae carbapenemase are a serious worldwide threat. The molecular identification of these pathogens is not routine in Brazilian hospitals, and a rapid phenotypic screening test is desirable.
Ana Paula Cury +4 more
doaj +8 more sources
Modified Hodge test as screening test for spreading Carbapenemase resistance has become more important [PDF]
Clinics, 2013 Dear Editor, We read the article by Cury et al. titled ‘‘The modified Hodge test is a useful tool for ruling out Klebsiella pneumoniae carbapenemase” with interest (1). The authors aimed to evaluate the modified Hodge test (MHT) as a phenotypic screening test for Klebsiella pneumoniae carbapenemase (KPC).
Mustafa Hatipoglu +5 more
doaj +7 more sources
Triton Hodge Test: Improved Protocol for Modified Hodge Test for Enhanced Detection of NDM and Other Carbapenemase Producers [PDF]
Journal of Clinical Microbiology, 2016 ABSTRACT Accurate detection of carbapenemase-producing Gram-negative bacilli is of utmost importance for the control of nosocomial spread and the initiation of appropriate antimicrobial therapy. The modified Hodge test (MHT), a carbapenem inactivation assay, has shown poor sensitivity in detecting the worldwide spread of New Delhi metallo-β ...
Lisandro Gonzalez +2 more
exaly +6 more sources
Modified Hodge test: A simple and effective test for detection of carbapenemase production [PDF]
Iranian Journal of Microbiology, 2011 Background and Objectives: Resistance among bacterial isolates is the leading cause of increased mortality and morbidity worldwide. Carbapenems once thought to be effective are becoming ineffective mostly due to the emergence of carbapenemase. This study
A Amjad +5 more
doaj +3 more sources
Functional categorization of carbapenemase-mediated resistance by a combined genotyping and two-tiered Modified Hodge Test approach [PDF]
Frontiers in Microbiology, 2015 The functional relationship between the detection of carbapenemase activity and phenotypic resistance in Gram-negative bacterial pathogens is often ill-defined. To address this issue, we developed a two-tiered Modified Hodge Test approach for carbapenemase detection and typing, in which the use of Pseudomonas aeruginosa strain PAO1 and Escherichia coli
Marcus H Wong, Sheng Chen
exaly +7 more sources
Phenotypic Detection of Carbapenemase Production in Carbapenem-Resistant Enterobacteriaceae by Modified Hodge Test and Modified Strip Carba NP Test. [PDF]
J Lab Physicians, 2021 Abstract Objective Carbapenems are last resort antibiotics for multidrug-resistant Enterobacteriaceae. However, resistance to carbapenem is increasing at an alarming rate worldwide leading to major therapeutic failures and increased mortality rate. Early and effective detection of carbapenemase producing carbapenem-resistant Enterobacteriaceae (CRE) is
Patidar N, Vyas N, Sharma S, Sharma B.
europepmc +4 more sources
Value of the modified Hodge test for detection of emerging carbapenemases in Enterobacteriaceae. [PDF]
J Clin Microbiol, 2012 ABSTRACT The modified Hodge test has an excellent sensitivity for detecting enterobacterial isolates producing Ambler class A (KPC) and class D (OXA-48) carbapenemases. Its sensitivity is low for NDM-1 producers (50%) but is increased to 85.7% by adding ZnSO 4 (100 μg/ml) in the culture medium.
Girlich D, Poirel L, Nordmann P.
europepmc +4 more sources
Screening for New Delhi metallo-β-lactamase-1 in Enterobacteriaceae: Is there a role for the modified Hodge test? [PDF]
Pak J Med Sci, 2015 Objective: The New Delhi metallo-?-lactamase-1 (NDM-1) enzyme is a plasmid-encoded enzyme that inactivates carbapenem antibiotics. This study aims to ascertain if the modified Hodge test (MHT) has a role in screening for NDM-1 in Enterobacteriaceae with reduced carbapenem susceptibility.Methods: Over a period of one year, all Enterobacteriaceae ...
Abidin NZ +5 more
europepmc +3 more sources
Evaluation of Modified Hodge Test as a Non-molecular Assay for Accurate Detection of KPC-producing Klebsiella pneumoniae. [PDF]
Pol J Microbiol, 2018 Abstract Klebsiella pneumoniae carbapenemase (KPC) have become a major therapeutic challenge because of its increasingly fast dissemination throughout the world. Accurate detection of KPC is essential for optimal treatment.
Ghasemnejad A, Doudi M, Amirmozafari N.
europepmc +5 more sources
Performance of quantification of Modified Hodge Test: an evaluation with Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae isolates. [PDF]
Biomed Res Int, 2014 Modified Hodge Test (MHT) has been suggested as screening tests for carbapenemases, but concerns regarding its difficult interpretation and common false-positive results obtained in the presence of otherβ-lactamases have been noted. This study aimed to quantify the enhanced growth formed by the indicator strain and thus evaluate the performance of a ...
Ribeiro VB +3 more
europepmc +4 more sources