Results 111 to 120 of about 26,843 (264)

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

An Orthodenticle Homeobox 2 (OTX2) Mutation in a Patient With Combined Pituitary Hormone Deficiency, Pituitary Malformation, and Retinitis Pigmentosa. [PDF]

Cureus, 2023
Araújo C, Baptista C, Paiva I.
europepmc   +1 more source

Gene expression patterns in anterior pituitary associated with quantitative measure of oestrous behaviour in dairy cows

, 2010
Intensive selection for high milk yield in dairy cows has raised production levels substantially but at the cost of reduced fertility, which manifests in different ways including reduced expression of oestrous behaviour.
Kommadath, A., Pas, M.F.W., te, Beerda, B., Wit, A.A.C., de, Veerkamp, R.F., Mulder, H.A., Woelders, H., Frijters, A.C.J., Smits, M.A.   +8 more
core   +1 more source

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

Interdisciplinary Medicine, EarlyView.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi, Siying Weng, Qiao Yin, Mengqi Li, Liang Shen, Enyou Qiao, Lu Gao, Yihan Wang, Yuxuan Li, Weifeng Luo, Qilin Zhang, Jing Wang, Jianfeng Feng, Qifei Cong   +13 more
wiley   +1 more source

An animal model of combined pituitary hormone deficiency disease

, 2010
LHX3 is a LIM-homeodomain transcription factor that has essential roles in pituitary and nervous system development in mammals. Children who are homozygous for recessive mutations in the LHX3 gene present with combined pituitary hormone deficiency ...
Colvin, Stephanie C., Colvin, Stephanie C   +1 more
core   +1 more source

Hydrogel‐based drug delivery systems for intracerebral hemorrhage with therapeutic advances and emerging roles of the bone–brain axis

Interdisciplinary Medicine, EarlyView.
Hydrogel‐based drug delivery systems offer a promising approach for treating intracerebral hemorrhage (ICH) by overcoming blood‐brain barrier limitations, enabling precise, sustained release of neuroprotective and anti‐inflammatory agents. These systems enhance treatment efficacy, but challenges remain in biosafety, drug penetration, and scalability ...
Haojun Shi, Min Chen, Yisheng Chen, MengYao Li, Jiale Ma, Zuozhen Yin, Li Wu, YangBao Miao, Zemin Ou, Ke Wu, Zhijie Xu, Lizhi Li, Shaocong Zhao, Shiwei He, Bin Huang, Guanwen He, Guanghui Wu, John H. Zhang, Liang Shi   +18 more
wiley   +1 more source

X-linked recessive combined pituitary hormone deficiency is mapped to Xp22.3–Xp11 in a Chinese family

, 2011
Genetic mutations have been identified in a modest proportion of patients with combined pituitary hormone deficiency (CPHD). We reported a 3-generation family consisting of 18 members, including 5 affected males (the proband, his 2 brothers, his cousin ...
Wang, Chun Lin, Shen, Zheng, Jun Fen Fu, Liang, Li, Chun Lin Wang, Chao Chun Zou, Guan Ping Dong, Zou, Chao Chun, Li Liang, Fu, Jun Fen, Dong, Guan Ping, Zheng Shen   +11 more
core   +1 more source

Evolving pituitary hormone deficits in primarily isolated GHD: a review and experts’ consensus

, 2020
Isolated growth hormone deficiency (GHD) is defined by growth failure in combination with retarded bone age, low serum insulin-like growth factor-1, and insufficient GH peaks in two independent GH stimulation tests.
Dirk Schnabel, Thomas Reinehr, Schnabel, Dirk, Reinehr, Thomas, Hauffa, Berthold, Markus Bettendorf, Bettendorf, Markus, Roland Pfäffle, Dörr, Helmuth-Günther, Joachim Woelfle, Woelfle, Joachim, Berthold Hauffa, Gerhard Binder, Pfäffle, Roland, Binder, Gerhard, Helmuth-Günther Dörr   +15 more
core   +1 more source

Nanoplastics: Methods, Exposure and Effects on Domestic, Farm and Wild Animals

Journal of Applied Toxicology, EarlyView.
ABSTRACT Nanoplastics (NPs) are synthetic polymer particles ranging in size from 1 nm to 1 μm that have been identified as a major concern for ecosystems and organisms due to their plethora of negative effects. The aim of this review is to provide a comprehensive overview of the knowledge relating to exposure and effects of NPs in domestic (i.e., farm ...
B. De Felice, M. Bertazzo, A. F. Tabaran, M. Parolini, R. P. Popa, A. Pintea, L. J. Spicer, A‐L. Nagy, F. Caloni   +8 more
wiley   +1 more source

Corticosterone Under Experimental Manipulation of Nutrition and Parasite Burden in a Wild Rodent System

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Environmental pressures shape survival and life‐history dynamics partly by triggering the release of glucocorticoids, whose short‐term benefits but long‐term costs make it essential to understand what drives their levels. Here, we used an experimental manipulation of two environmental stressors—food availability and parasite burden—to directly
Sarah E. Wolf, Olga Dłużniewska, Simon A. Babayan, Amy B. Pedersen, Tom J. Little   +4 more
wiley   +1 more source