Results 121 to 130 of about 3,553,850 (264)

Association between serum prolactin and anterior pituitary dysfunction in pituitary stalk interruption syndrome: a retrospective study of 155 patients from a large tertiary medical center in China

BMC Endocrine Disorders
Background Pituitary stalk interruption syndrome (PSIS) is a rare hypothalamic-pituitary disorder causing progressive anterior pituitary deficiency. Subtle early symptoms and unreliable sex hormone levels in prepubertal patients complicate diagnosis of ...
Lei Fu, Yan Xiao, Deyue Jiang, Lingtong Ye, Yiming Mu, Zhaohui Lyu, Qinghua Guo   +6 more
doaj   +1 more source

Conserved SERPINE2 function maintains ovarian estrogen production to support fertility in goats and mice

iMetaOmics, EarlyView.
Single‐nucleus RNA sequencing and functional profiling of goat ovaries with divergent litter sizes revealed prolificacy‐associated granulosa cell (GC) states characterized by enhanced proliferation‐ and steroidogenesis‐related features, together with altered predicted cell–cell communication.
Sanbao Zhang, Yirong Wei, Xiaoping Guo, Ruimen Zhang, Yingming Wei, Yanna Huang, Qinyang Jiang   +6 more
wiley   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Bidirectional Pathological Axis Between Alzheimer's Disease and Circadian Rhythm Disturbance: Mechanisms and Therapeutic Strategies

iNew Medicine, EarlyView.
This graphical abstract illustrates a bidirectional vicious cycle between Alzheimer’s disease (AD) and circadian rhythm disturbance (CRD). On the one hand, AD pathology, including amyloid‐β (Aβ) plaque deposition and tau hyperphosphorylation, may damage the suprachiasmatic nucleus (SCN) and disrupt melatonin signaling, leading to sleep fragmentation ...
Jiajia Qin, Xianfeng Yu, Yayu Wang, Xiaohan Song, Yuehua Wang, Zhixin Wang, Wei Miao, Xudong Yang, Jiajia Zhu, Xiaoqun Zhu, Maria‐Trinidad Herrero   +10 more
wiley   +1 more source

Analysis of ProP1 Gene in a Cohort of Tunisian Patients with Congenital Combined Pituitary Hormone Deficiency. [PDF]

J Clin Med, 2022
Moalla M, Mnif-Feki M, Safi W, Charfi N, Mejdoub-Rekik N, Abid M, Hadj Kacem F, Hadj Kacem H.   +7 more
europepmc   +1 more source

Nanoplastics: Methods, Exposure and Effects on Domestic, Farm and Wild Animals

Journal of Applied Toxicology, EarlyView.
ABSTRACT Nanoplastics (NPs) are synthetic polymer particles ranging in size from 1 nm to 1 μm that have been identified as a major concern for ecosystems and organisms due to their plethora of negative effects. The aim of this review is to provide a comprehensive overview of the knowledge relating to exposure and effects of NPs in domestic (i.e., farm ...
B. De Felice, M. Bertazzo, A. F. Tabaran, M. Parolini, R. P. Popa, A. Pintea, L. J. Spicer, A‐L. Nagy, F. Caloni   +8 more
wiley   +1 more source

Potential Neuroendocrine Disruption by Benzodiazepines and Its Impact on Male Fertility

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neuroactive substances have emerged as potent endocrine disruptors affecting male reproductive health through central and peripheral mechanisms. Among these, benzodiazepines, which are widely used for the management of anxiety, insomnia, epilepsy, and neuromuscular disorders, are known as GABA A (gamma‐aminobutyric acid type A) receptor ...
Ana Clara Melo Andrade de Rodrigues, Julia Gonçalves Rodrigues, Marcos de Lucca Moreira Gomes, Fernanda Carolina Ribeiro Dias   +3 more
wiley   +1 more source

Functional analysis of adrenocorticotropic-hormone–producing pituitary cells derived from human pluripotent stem cells in murine and primate models of hypopituitarism

Stem Cell Research & Therapy
Background Hypopituitarism has a prevalence of approximately 45.5 cases per 100,000 population, is therefore not a rare condition. Hypopituitarism does not resolve spontaneously and is designated as an intractable disease.
Tatsuma Kondo, Hidetaka Suga, Kenji Watari, Shiori Taga, Mayu Sakakibara, Mika Soen, Ikuo Kawamoto, Kazuki Nishida, Ryo Emoto, Yukihiro Shiraki, Sasaki Hiroo, Tsutomu Miwata, Toshiaki Hirose, Yuichi Nagata, Kazuhito Takeuchi, Tokushige Nakano, Atsushi Ikeda, Atsushi Kuwahara, Atsushi Enomoto, Hideaki Tsuchiya, Hiroshi Arima, Ryuta Saito   +21 more
doaj   +1 more source

Offspring Global DNA Methylation is not Affected by Parental Developmental Stress Experience in a Passerine Species

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Rapid phenotypic change may be mediated by intergenerational transmission of early developmental experiences. In birds, exposure to glucocorticoids during early development can alter global DNA methylation and gene expression. However, DNA methylation is labile, and it is currently unclear whether the impacts of stress suffered during juvenile
Anna Miltiadous, Harrison J. F. Eyck, Ondi L. Crino, Lee A. Rollins, Damien Callahan, Katherine L. Buchanan   +5 more
wiley   +1 more source

Novel compound heterozygous variants in the LHX3 gene caused combined pituitary hormone deficiency: A case report. [PDF]

World J Clin Cases, 2022
Lin SZ, Ma QJ, Pang QM, Chen QD, Wang WQ, Li JY, Zhang SL.   +6 more
europepmc   +1 more source