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Combined vaccines for prophylaxis of infectious conditions
In recent years, the application of vaccines shows limitations, including the high number of vaccine administrations and the fear of safety and effectiveness.
Pravin Shende, Mansi Waghchaure
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Development of Nasal Vaccines and the Associated Challenges
Viruses, bacteria, fungi, and several other pathogenic microorganisms usually infect the host via the surface cells of respiratory mucosa. Nasal vaccination could provide a strong mucosal and systemic immunity to combat these infections.
Xuanxuan Nian +5 more
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The Epidemiology of Influenza and the Associated Vaccines Development in China: A Review
Influenza prevention and control has been one of the biggest challenges encountered in the public health domain. The vaccination against influenza plays a pivotal role in the prevention of influenza, particularly for the elderly and small children ...
Jiayou Zhang +6 more
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This phase III clinical trial aimed to assess the safety and demonstrate the immunogenicity of a candidate freeze-dried purified Vero cell-based rabies vaccine (PVRV-WIBP) developed for human use.
Xiaoyuan Huang +20 more
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30-Year Development of Inactivated Virus Vaccine in China
Inactivated vaccines are vaccines made from inactivated pathogens, typically achieved by using chemical or physical methods to destroy the virus’s ability to replicate.
Jinrong Shi +4 more
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Seasonal influenza, causes hundreds of thousands of deaths annually, posing a severe threat to human health. Currently available influenza vaccines are targeted only at specific strains or conserved epitopes; however, these vaccines are not completely ...
Ning Ma +10 more
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Coping Strategies for Pertussis Resurgence
Pertussis (whooping cough) is a respiratory disease caused primarily by Bordetella pertussis, a Gram-negative bacteria. Pertussis is a relatively contagious infectious disease in people of all ages, mainly affecting newborns and infants under 2 months of
Xuanxuan Nian +4 more
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The resurgence of pertussis in vaccinated communities may be related to the reduced long-term immunity induced by acellular pertussis vaccines. Therefore, developing improved pertussis vaccine candidates that could induce strong Th1 or Th17 cellular ...
Baifeng Yang +11 more
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Infections are still a leading cause of morbidity and mortality in children under five years of age, most of which can be prevented by vaccination. However, there are too many vaccines to be administered, increasing the cost of immunization and visits to the paediatrician.
S K, Jatana, Mng, Nair
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TRAF3 deficiency in MDCK cells improved sensitivity to the influenza A virus
Tumor necrosis factor receptor-associated factor 3 (TRAF3), an adaptor protein, has significant and varying effects on immunity depending on cell types. The role of TRAF3 in Madin-Darby Canine Kidney Epithelial (MDCK) cell resistance to influenza A virus
Yang Le +14 more
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