Results 1 to 10 of about 2,609 (166)

Development of Nasal Vaccines and the Associated Challenges

Pharmaceutics, 2022
Viruses, bacteria, fungi, and several other pathogenic microorganisms usually infect the host via the surface cells of respiratory mucosa. Nasal vaccination could provide a strong mucosal and systemic immunity to combat these infections.
Xuanxuan Nian, Jiayou Zhang, Shihe Huang, Kai Duan, Xinguo Li, Xiaoming Yang   +5 more
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Development of an mRNA vaccine against a panel of heterologous H1N1 seasonal influenza viruses using a consensus hemagglutinin sequence

Emerging Microbes and Infections, 2023
Seasonal influenza, causes hundreds of thousands of deaths annually, posing a severe threat to human health. Currently available influenza vaccines are targeted only at specific strains or conserved epitopes; however, these vaccines are not completely ...
Ning Ma, Zhi-Wu Xia, Zhe-Gang Zhang, Xuan-Xuan Nian, Xue-Dan Li, Zheng Gong, Guo-Mei Zhang, Yang Le, Rong Zhou, Jia-You Zhang, Xiao-Ming Yang   +10 more
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Safety and immunogenicity of rabies vaccine (PVRV-WIBP) in healthy Chinese aged 10–50 years old: Randomized, blinded, parallel controlled phase III clinical study

Human Vaccines & Immunotherapeutics, 2023
This phase III clinical trial aimed to assess the safety and demonstrate the immunogenicity of a candidate freeze-dried purified Vero cell-based rabies vaccine (PVRV-WIBP) developed for human use.
Xiaoyuan Huang, Jing Liang, Lili Huang, Xuanxuan Nian, Wei Chen, Jiayou Zhang, Xiao Xu, Xuan Lin, Yue Wang, Jinrong Shi, Lanxin Jia, Qingliang Li, Qianxi Wang, Kai Duan, Xinguo Li, Yaqi Ji, Feixia Peng, Wei Zhang, Zhiqiang Xie, Yanxia Wang, Xiaoming Yang   +20 more
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30-Year Development of Inactivated Virus Vaccine in China

Pharmaceutics, 2023
Inactivated vaccines are vaccines made from inactivated pathogens, typically achieved by using chemical or physical methods to destroy the virus’s ability to replicate.
Jinrong Shi, Ailin Shen, Yao Cheng, Chi Zhang, Xiaoming Yang   +4 more
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Coping Strategies for Pertussis Resurgence

Vaccines, 2023
Pertussis (whooping cough) is a respiratory disease caused primarily by Bordetella pertussis, a Gram-negative bacteria. Pertussis is a relatively contagious infectious disease in people of all ages, mainly affecting newborns and infants under 2 months of
Xuanxuan Nian, Hongbo Liu, Mengyao Cai, Kai Duan, Xiaoming Yang   +4 more
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The Epidemiology of Influenza and the Associated Vaccines Development in China: A Review

Vaccines, 2022
Influenza prevention and control has been one of the biggest challenges encountered in the public health domain. The vaccination against influenza plays a pivotal role in the prevention of influenza, particularly for the elderly and small children ...
Jiayou Zhang, Xuanxuan Nian, Xuedan Li, Shihe Huang, Kai Duan, Xinguo Li, Xiaoming Yang   +6 more
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Liposome and QS-21 Combined Adjuvant Induces theHumoral and Cellular Responses of Acellular Pertussis Vaccine in a Mice Model

Vaccines, 2023
The resurgence of pertussis in vaccinated communities may be related to the reduced long-term immunity induced by acellular pertussis vaccines. Therefore, developing improved pertussis vaccine candidates that could induce strong Th1 or Th17 cellular ...
Baifeng Yang, Dewu Zhu, Yisi Zhou, Beizhe Gong, Yuan Hu, Jiayou Zhang, Shihe Huang, Xuanxuan Nian, Xinghang Li, Xinguo Li, Kai Duan, Xiaoming Yang   +11 more
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TRAF3 deficiency in MDCK cells improved sensitivity to the influenza A virus

Heliyon, 2023
Tumor necrosis factor receptor-associated factor 3 (TRAF3), an adaptor protein, has significant and varying effects on immunity depending on cell types. The role of TRAF3 in Madin-Darby Canine Kidney Epithelial (MDCK) cell resistance to influenza A virus
Yang Le, Jiayou Zhang, Zheng Gong, Zhegang Zhang, Xuanxuan Nian, Xuedan Li, Daiguan Yu, Ning Ma, Rong Zhou, Guomei Zhang, Bo Liu, Lu Yang, Baiqi Fu, Xiuqin Xu, Xiaoming Yang   +14 more
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Suspended cell lines for inactivated virus vaccine production

Expert Review of Vaccines, 2023
Introduction Inactivated virus vaccines are the most widely used tool to prevent disease. To meet vaccine production demands, increasing attention has been placed on identifying methods to improve vaccine production efficiency. The use of suspended cells
Jiayou Zhang, Zhenyu Qiu, Siya Wang, Zhenbin Liu, Ziling Qiao, Jiamin Wang, Kai Duan, Xuanxuan Nian, Zhongren Ma, Xiaoming Yang   +9 more
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A case of human rabies with a long incubation period in Wuhan

IDCases, 2021
Rabies remains endemic in China and continues to pose a major threat to public health with a nearly 100 % case fatality rate in humans. We confirmed a case of human rabies in Wuhan, in May 2018.
Meng Shengli, Li Qian, Sun Yan, Wu Wenjuan, Wu Jie, Shi Jinrong, Wang Zejun, Li Xingguo   +7 more
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