Results 191 to 200 of about 2,619,226 (252)
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim The aim of this systematic review was to assess all available clinical data regarding the use of a single dose of basiliximab in solid organ transplantation compared to the standard double dosage, with particular interest in efficacy, safety and cost‐savings.
Alessio Provenzani +4 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló +5 more
wiley +1 more source
Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source
Decoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe
British Journal of Clinical Pharmacology, EarlyView.Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...
Olivia C. Lewis +4 more
wiley +1 more source
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Infectious Disease Clinics of North America, 2001
The past decade has shown a marked increase in the number of vaccines currently licensed and recommended for use in infants and children. Although most agree that it is desirable to combine as many of these vaccines as possible into a single injection, safety and efficacy must not be sacrificed.
K M, Edwards, M D, Decker
+6 more sources
The past decade has shown a marked increase in the number of vaccines currently licensed and recommended for use in infants and children. Although most agree that it is desirable to combine as many of these vaccines as possible into a single injection, safety and efficacy must not be sacrificed.
K M, Edwards, M D, Decker
+6 more sources
International Journal of Technology Assessment in Health Care, 1994
AbstractThe availability of new vaccines for pediatric use provides an unprecedented opportunity to prevent serious infectious diseases and their associated morbidity and mortality. However, each new product entails the need for additional injections that could become so numerous as to discourage the administration of new vaccines.
R W, Ellis, R G, Douglas
openaire +4 more sources
AbstractThe availability of new vaccines for pediatric use provides an unprecedented opportunity to prevent serious infectious diseases and their associated morbidity and mortality. However, each new product entails the need for additional injections that could become so numerous as to discourage the administration of new vaccines.
R W, Ellis, R G, Douglas
openaire +4 more sources
The combination of targeted vaccination and ring vaccination
Chaos: An Interdisciplinary Journal of Nonlinear Science, 2021Complex networks have become an important tool for investigating epidemic dynamics. A widely concerned research field for epidemics is to develop and study mitigation strategies or control measures. In this paper, we devote our attention to ring vaccination and targeted vaccination and consider the combination of them. Based on the different roles ring
Weiqiang Li +3 more
openaire +3 more sources
VacciTUTOR, 2022
Combination vaccines have been around since 1945 (trivalent influenza vaccine) and they combine either different serotypes of one microorganism (e.g., influenza or pneumococcal vaccines) or different microorganisms (e.g., DTP combinations). Potential chemical and physical interactions, unpredictable immunological interactions, and in one instance ...
Alejandra Esteves-Jaramillo +1 more
openaire +1 more source
Combination vaccines have been around since 1945 (trivalent influenza vaccine) and they combine either different serotypes of one microorganism (e.g., influenza or pneumococcal vaccines) or different microorganisms (e.g., DTP combinations). Potential chemical and physical interactions, unpredictable immunological interactions, and in one instance ...
Alejandra Esteves-Jaramillo +1 more
openaire +1 more source
Pediatric combination vaccines
Current Opinion in Pediatrics, 1999There will be an increasing demand for safe and effective combination vaccines as more paediatric vaccines are developed and licensed for new indications. The successful introduction of new combination vaccines into the childhood immunization schedule has the potential to improve vaccine coverage and thus reduce morbidity and mortality from childhood ...
Choo, S, Finn, A
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Journal of Infectious Diseases, 1996
The increasing number of useful vaccines for infants and children justifies the development of new combined vaccines. New methodologies are needed for evaluation of efficacy, especially for acellular pertussis vaccines. Such evaluation requires the use of previous immunogenicity studies as a means to seek immune interference that might lead to ...
P, Bégué, E, Grimprel
openaire +2 more sources
The increasing number of useful vaccines for infants and children justifies the development of new combined vaccines. New methodologies are needed for evaluation of efficacy, especially for acellular pertussis vaccines. Such evaluation requires the use of previous immunogenicity studies as a means to seek immune interference that might lead to ...
P, Bégué, E, Grimprel
openaire +2 more sources