Results 111 to 120 of about 2,441,843 (293)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Heterosis and combining ability for yield and other agronomic traits in Triticale

Open Agriculture, 2018
The estimation of genetic parameters such as heterosis (Mh), heterobeltiosis (Hh), general combining ability (GCA) and specific combining ability (SCA) allows inferences about the predominant action of the genes, indicates the appropriate selection ...
Ferrari Enzo, Picca Aurora, Domínguez Rodolfo, Paccapelo Héctor   +3 more
doaj   +1 more source

Forecasting Organic Food Prices: Testing and Evaluating Conditional Predictive Ability [PDF]

Organic farmers, wholesalers, and retailers need reliable price forecasts to improve their decision- making practices. This paper presents a methodology and protocol to select the best-performing method from several time and frequency domain candidates ...
Escalante, Cesar L., Gubanova, Tatiana, Lohr, Luanne, Park, Timothy A.   +3 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Combining abilitys for yield components in sunflower

Selekcija i Semenarstvo, 2000
In order to develop new single-cross sunflower hybrids with an altered plant model and a high genetic potential for seed yield and oil content, it is essential to study the combining abilitys of the inbred lines. Full diallel crosses with six genetically divergent sunflower inbreds were carried out in order to study the mode of inheritance and ...
Hladni Nada, Škorić Dragan, Kraljević-Balalić Marija   +2 more
openaire   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Diallel mixed-model analyses to select superior maize parental lines for Azospirillum brasilense and nitrogen-use efficiency

Crop Breeding and Applied Biotechnology, 2018
Breeding new maize varieties that take up more N from the soil and increase N fixation is a crucial source of combined nitrogen in agricultural systems.
Rodolfo Buzinaro, Gustavo Hugo Ferreira de Oliveira, Camila Baptista do Amaral, Claudio Lopes de Souza Junior, Gustavo Vitti Moro   +4 more
doaj  

Heritability and combined parental information to define the number of crosses in circulant diallels

Crop Breeding and Applied Biotechnology, 2021
In many agricultural crops, the number of parents used in cross breeding make it difficult to obtain all possible hybrids in diallels. Therefore, using maize as a model plant and based on traits with high and low heritabilities, the aim of the present ...
Gabriela Inocente, Deoclécio Domingos Garbuglio, Pedro Mario de Araújo, Paulo Maurício Ruas   +3 more
doaj  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

STUDY OF COMBINING ABILITY OF NEW SELF-POLLINATED LINES OF MAIZE IN CENTRAL PART OF KRASNODAR KRAI

Зерновое хозяйство России, 2018
It’s common knowledge that any success of breeding work largely depends on initial material. The staff of Krasnodar RIA named after P.P. Lukiyanenko is carrying out a significant work in breeding, assessment and classification of new initial material for
I. M. Chilashvili, A. I. Suprunov, A. Yu. Slashchev   +2 more
doaj   +2 more sources