Results 191 to 200 of about 10,435,327 (303)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Tester selection for combining ability estimation of storage root yield and sweetpotato virus disease in sweetpotato breeding. [PDF]

Sci Rep
Swanckaert J, Dos Santos IG, Chaves SFS, Ssali R, Mwanga ROM, Azevedo CF, Mendes TO, De Boeck B, Eyzaguirre R, Kitavi M, Gemenet DC, Andrade M, Grüneberg WJ, Lindqvist-Kreuze H, Yencho GC, Campos H, da Silva Pereira G.   +16 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Estimation of heterosis, combining ability and reciprocal effects for body weight in four genetic groups of chicken from a full diallel cross. [PDF]

Poult Sci
Teshome P, Goshu G, Esatu W, Dessie T.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Exploitation of heterosis and combining ability potential for improvement in okra (Abelmoschus esculentus L.). [PDF]

Sci Rep
Ranga AD, Vikram A, Kumar R, Dogra RK, Sharma R, Sharma HR.   +5 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Exploring molecular variation and combining ability of local and exotic bread wheat genotypes under well-watered and drought conditions. [PDF]

PeerJ
Motawei MI, Kamara MM, Rehan M.
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Inheritance of Some Salt Tolerance-Related Traits in Bread Wheat (<i>Triticum aestivum</i> L.) at the Seedling Stage: A Study of Combining Ability. [PDF]

Plants (Basel)
Hadji T, Boulacel M, Ghennai A, Hadji M, Kebaili FF, Khugaev CV, Kucher OD, Utkina AO, Konovalova AP, Rebouh NY.   +9 more
europepmc   +1 more source