KB2764 interacted with alpha‐enolase (ENO1) and pyruvate kinase M (PKM), ultimately leading to PKM phosphorylation of ENO1. KB2764 consequently increased mitochondrial ATP production and decreased glycolysis dependence. Furthermore, the action of KB2764 extends its application to extend the lifespan of Caenorhabditis elegans.
Yun Haeng Lee+13 more
wiley +1 more source
Carbon Speciation and Solubility in Silicate Melts
This book is Open Access. A digital copy can be downloaded for free from Wiley Online Library.
Explores the behavior of carbon in minerals, melts, and fluids under extreme conditions
Carbon trapped in diamonds and carbonate-bearing rocks in subduction zones are examples of the continuing exchange of substantial carbon ...
Natalia Solomatova+2 more
wiley +2 more sources
Evaluation of the Genotoxicity and Cytotoxicity of Bioceramic Endodontic Sealers in HepG2 and V79 Cell Lines: An In Vitro Study Using the Comet and Micronucleus Assays. [PDF]
Tadin A+6 more
europepmc +1 more source
RBM39 Promotes Base Excision Repair to Facilitate the Progression of HCC by Stabilising OGG1 mRNA
Targeting RBM39 attenuates BER via destabilising OGG1 mRNA and potentiates KBrO3‐induced oxidative stress in HCC. Our study represents a valuable treatment strategy combining indisulam and an oxidative stress inducer in HCC. ABSTRACT Targeting base excision repair (BER) has been an attractive strategy in cancer therapeutics.
Hongda An+7 more
wiley +1 more source
Genotoxicity of Coffee, Coffee By-Products, and Coffee Bioactive Compounds: Contradictory Evidence from In Vitro Studies. [PDF]
Monazzah M, Lachenmeier DW.
europepmc +1 more source
Polarization of Comet Arend–Roland [PDF]
M. K. V. Bappu, S. D. Sinvhal
openalex +1 more source
67P/Churyumov-Gerasimenko, a Jupiter family comet with a high D/H ratio
K. Altwegg+34 more
semanticscholar +1 more source
Abstract Introduction Various novel harm reduction services leverage technology to reduce the rising number of drug poisoning deaths, particularly among those who use drugs alone. There is significant variability in terminology and outcome measures in reporting these interventions, complicating efforts to build a comprehensive knowledge base.
William Rioux+16 more
wiley +1 more source
Rapid and Accurate Genotoxicity Assessment Using the Neutral Comet Assay in <i>Cyprinus carpio</i> Cells. [PDF]
So B+11 more
europepmc +1 more source