Results 271 to 280 of about 58,125 (347)

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, Volume 13, Issue 25, 4 May 2026.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, Volume 13, Issue 27, 13 May 2026.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

Relevance of Comet Assay and Phosphorylated-Hsp90α in Cancer Patients' Peripheral Blood Leukocytes as Tools to Assess Cisplatin-based Chemotherapy Clinical Response and Disease Outcome. [PDF]

J Histochem Cytochem
Sottile ML, Gómez LC, Redondo A, Ibarra J, García MB, Gonzalez L, Vargas-Roig LM, Nadin SB.   +7 more
europepmc   +1 more source

Helmeted hornbill cranial kinesis: Balancing mobility and stability in a high‐impact joint

The Anatomical Record, Volume 309, Issue 5, Page 1299-1312, May 2026.
Abstract Prokinesis—in which a craniofacial joint allows the rostrum to move relative to the braincase—is thought to confer diverse advantages in birds, mostly for feeding. A craniofacial joint would, however, be a weak link if cranial stability is important. Paradoxically, we have identified a craniofacial joint in helmeted hornbills (Rhinoplax vigil),
Mike Schindler, Benjamin Flaum, Armita Razieh Manafzadeh, Viktoriia Kamska, Kanmani Chandra Rajan, Maria Jose Robles Malagamba, Ruien Hu, Daniel Baum, Mason N. Dean   +8 more
wiley   +1 more source

Phenolic Content, Antioxidant Activity, Phytochemical Diversity, and Toxicological Potential of Tetradenia riparia (Hochst.) Codd Leaves

Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.
ABSTRACT Tetradenia riparia (Hochst.) Codd is a medicinal plant widely used in traditional medicine. However, comprehensive studies integrating its chemical composition, antioxidant capacity, and toxicological safety are still limited. This study aimed to characterize the phenolic content, antioxidant activity, phytochemical diversity, and ...
Caroline dos Santos Giuliani, Carla Andressa Almeida Farias, Patrícia Kolling Marquezan, Karoline Longo de Aguiar, Elize Musachio, Andreara Rodrigues dos Reis, Nathália Cardoso de Afonso Bonotto, Fernanda Barbisan, Milene Teixeira Barcia, Ana Lúcia Souza Silva Mateus, Aline Sobreira Bezerra, José Laerte Nörnberg   +11 more
wiley   +1 more source

Analysis of DNA Double-Stranded Breaks Using the Comet Assay in Planarians.

Methods Mol Biol, 2022
Barghouth PG, Rojas S, O'Dell LR, Betancourt AM, Oviedo NJ.   +4 more
europepmc   +1 more source

Parvimonas micra promotes carcinogenesis of colorectal cancer through phenyllactic acid‐induced DNA damage

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
Multiomics analysis of the faecal samples from CRC patients found that upregulation of P. micra and PLA was associated with the CRC development. PLA from P. micra via pdhD genes could induce DNA damage via AHR signalling pathway to mediate carcinogenesis.
Shuang Guo, Mujia Cao, Jinjie Wu, Wenhao Ma, Dayi Liang, Hongyu Xie, Yanchun Xie, Zhanhao Luo, Peng Lai, Danling Liu, Wanyi Zeng, Jingbiao Zheng, Mengze Xing, Xiqi Yin, Min Xia, Zhen He   +15 more
wiley   +1 more source

Survival after treatment with X-ray and Wortmannin or incubation with topoisomerase inhibitors, and comet assays

, 2011
Naoko Shiomi, Mori Masahiko, Hideo Tsuji, Imai Takashi, Hirokazu Inoue, Satoshi Tateishi, Masaru Yamaizumi, Tadahiro Shiomi   +7 more
openalex   +1 more source

Narrative Horizons: Deliberate Derangement in Oceanic Climate Fiction

Future Humanities, Volume 4, Issue 1, May 2026.
ABSTRACT Although we live in the Anthropocene—the geological age of humankind, wherein humans have measurably impacted the biosphere—we struggle to narrate the Anthropocene. In particular, we struggle to give narrative shape to its foremost feature: anthropogenic climate change.
Mark Celeste
wiley   +1 more source

The Impact of Genotoxicity in Coke Oven Workers: Systematic Review With Meta‐Analysis

Journal of Applied Toxicology, Volume 46, Issue 5, Page 1460-1475, May 2026.
ABSTRACT This systematic review (SR) with meta‐analysis investigates the genotoxicity potential of coke oven workers (COWs) exposed to polycyclic aromatic hydrocarbons (PAHs) through a comprehensive analysis of studies retrieved from PubMed, SCOPUS, and Web of Science.
Thiago Guedes Pinto, Vinícius Fialho do Nascimento, Giovanna Abreu Holanda Guerra, Wilton Mitsunari Takeshita, Raquel Alves Sales, Andrea Cristina de Moraes Malinverni, Luciana Lopes Guimaraes, Daniel Araki Ribeiro   +7 more
wiley   +1 more source