Results 71 to 80 of about 7,027 (228)

Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li, Jiri Aubrecht, Tatyana Y. Doktorova, Danyel Jennen, J. Christopher Corton, Roland Froetschl, Roman Mezencev, Carole L. Yauk   +7 more
wiley   +1 more source

Analyzing the Onset of Cometary Activity by the Jupiter-family Comet 2023 RN3

The Astronomical Journal
We utilize serendipitous observations from the Asteroid Terrestrial-impact Last Alert System (ATLAS) and the Zwicky Transient Facility in addition to targeted follow-up observations from the Las Cumbres Observatory (LCO) and Liverpool Telescope to ...
Matthew M. Dobson, Megan E. Schwamb, Alan Fitzsimmons, Michael S. P. Kelley, Carrie E. Holt, Joseph Murtagh, Henry H. Hsieh, Larry Denneau, Nicolas Erasmus, A. N. Heinze, Luke J. Shingles, Robert J. Siverd, Ken W. Smith, John L. Tonry, Henry Weiland, David. R. Young, Tim Lister, Edward Gomez, Joey Chatelain, Sarah Greenstreet   +19 more
doaj   +1 more source

DNA Damaging Effects, Oxidative Stress Responses and Cholinesterase Activity in Blood and Brain of Wistar Rats Exposed to Δ⁹-Tetrahydrocannabinol

Molecules, 2019
Currently we are faced with an ever-growing use of Δ9-tetrahydrocannabinol (THC) preparations, often used as supportive therapies for various malignancies and neurological disorders.
Nevenka Kopjar, Nino Fuchs, Suzana Žunec, Anja Mikolić, Vedran Micek, Goran Kozina, Ana Lucić Vrdoljak, Irena Brčić Karačonji   +7 more
doaj   +1 more source

ID3 deficiency alters chromatin accessibility at DSB sites and enhances vulnerability to HDAC inhibition

International Journal of Cancer, EarlyView.
What's New? Errors in DNA double‐strand break (DSB) repair can lead to mutations, chromosomal instability, and ultimately cancer. Inhibitor of DNA‐binding 3 (ID3), a transcriptional repressor, is crucial to promoting DSB repair and helping maintain genome stability. Here, the authors investigated ID3 regulation of DNA repair via chromatin accessibility
Giuditta Della Corte, Hossam Eldesouky, Julia Puchan, Sercan Öz, Elena Everatt, Ashish Goyal, Gianluca Sigismondo, Udo Oppermann, Christoph Plass, Dieter Weichenhan, Ali Bakr   +10 more
wiley   +1 more source

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, EarlyView.
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

Dynamics of Comets: Recent Developments and New Challenges [PDF]

Symposium - International Astronomical Union, 1994
There is a broad consensus that long-period comets come from a huge reservoir surrounding the solar system, as proposed originally by Oort. Yet, the classical picture of the Oort cloud has substantially changed during the last decade. In addition to passing stars, the tidal force of the galactic disk and giant molecular clouds have also been identified
openaire   +1 more source

Advances and Prospects of Stereotactic Radiosurgery and Stereotactic Ablative Body Radiotherapy: Evolving Paradigms in Precision Oncology

Med Research, EarlyView.
The graphical abstract outlines the progressive development and impact of stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT). Technological Evolution illustrates the transition from brachytherapy with single‐dose, LDR/HDR schedules to fractionated radiotherapy, three‐dimensional conformal radiotherapy (3DCRT) and Gamma Knife ...
Jing Zhang, Wenhao Xu, Weiqing Lu, Yingxuan Lin, Luoxi He, Zonglin Lv, Yiliyaer Nuerrula, Zouting, Zhen Zhang, Hailiang Zhang, Xuejun Ma   +10 more
wiley   +1 more source

The Comet Assay for the Evaluation of Genotoxic Potential of Landfill Leachate

The Scientific World Journal, 2012
Genotoxic assessment of landfill leachate before and after biological treatment was conducted with two human cell lines (Me45 and NHDF) and Daphnia magna somatic cells. The alkali version of comet assay was used to examine genotoxicity of leachate by DNA
Kamila Widziewicz, Joanna Kalka, Magdalena Skonieczna, Paweł Madej   +3 more
doaj   +1 more source

Viscosity Reduction in Diluted Polyethylene Melts: A Comparative Study of Semiempirical, Viscoelastic, and Equation‐of‐State Modeling Frameworks

Polymer Engineering &Science, EarlyView.
Schematic of the in‐line rheometry setup and the evaluation of three distinct modeling frameworks (semiempirical, viscoelastic, and EOS) to predict viscosity reduction in diluted polyethylene melts via time‐concentration superposition (Illustration generated via ChatGPT).
Ernst Georg Viehböck, Alexander Hammer, Markus Kirchmayr, Christof Murnig, Christian Paulik, Gerald Berger‐Weber   +5 more
wiley   +1 more source

The thrombin receptor (PAR1) is associated with microtubules, mitosis and process formation in glioma cells

Heliyon
The cell surface protease-activated receptor 1 (PAR1) is overexpressed in glioblastoma multiforme (GBM). We studied the function and structure of intracellular microtubule (MT) and PAR1 in a tubulin-mediated process.
Valery Golderman, Shany Guly Gofrit, Yanina Ivashko-Pachima, Illana Gozes, Joab Chapman, Efrat Shavit-Stein   +5 more
doaj   +1 more source