Results 51 to 60 of about 8,464 (293)

Light‐Switched Mesenchymal Stem Cells for In Situ Exosome Amplification in Craniofacial Bone Defect Reconstruction

Advanced Science, EarlyView.
Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu, Yajing Liu, Shuman Wang, Xiaoming Bai, Luyun Zhang, Yuwei Liu, Zhiwen Fu, Chen Shi   +7 more
wiley   +1 more source

On the Early Thermal Processing of Planetesimals during and after the Giant Planet Instability

The Planetary Science Journal
Born as ice-rich planetesimals, cometary nuclei were gravitationally scattered onto their current orbits in the Kuiper Belt and the Oort Cloud during the giant planets’ dynamical instability in the early stages of our solar system’s history.
Anastasios Gkotsinas, David Nesvorný, Aurélie Guilbert-Lepoutre, Sean N. Raymond, Nathan Kaib   +4 more
doaj   +1 more source

PhosSight: A Unified Deep Learning Framework Boosting and Accelerating Phosphoproteome Identification to Enable Biological Discoveries

Advanced Science, EarlyView.
PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang, Zhiyuan Cheng, Chengying She, Hongwei Zhao, Jiahui Zhang, Lin Lv, Zhihao Yan, Hongwen Zhu, Lizhuang Liu, Yan Fu, Xinpei Yi   +10 more
wiley   +1 more source

Properties of mass-loading shocks, 2. Magnetohydrodynamics

, 1992
The one-dimensional magnetohydrodynamics of shocked flows subjected to significant mass loading are considered. Recent observations at comets Giacobini-Zinner and Halley suggest that simple nonreacting MHD is an inappropriate description for active ...
Oughton, Sean, Neubauer, F. M., Zank, Gary P., Webb, G. M.   +3 more
core   +1 more source

Jupiter Co-Orbital Comet P/2023 V6 (PANSTARRS): Orbital History and Modern Activity State

The Astrophysical Journal Letters
The discovery of the transient Jupiter co-orbital comet P/2019 LD2 (ATLAS) drew significant interest. Not only will LD2 transition between being a Centaur and a Jupiter-family comet (JFC) in 2063, the first time this process can be observed as it happens,
Theodore Kareta, John W. Noonan, Kathryn Volk, Ryder H. Strauss, David Trilling   +4 more
doaj   +1 more source

Alpha 7 nicotinic receptors attenuate neurite development through calcium activation of calpain at the growth cone.

PLoS ONE, 2018
The α7 nicotinic acetylcholine receptor (nAChR) is a ligand-gated ion channel that plays an important role in cellular calcium signaling contributing to synaptic development and plasticity, and is a key drug target for the treatment of neurodegenerative ...
Justin R King, Nadine Kabbani
doaj   +1 more source

Dynamical constraints on the origin of Main Belt comets [PDF]

Meteoritics & Planetary Science, 2009
Abstract— In an effort to understand the origin of Main Belt comets (MBCs) 7968 Elst‐Pizzaro, 118401, and P/2005 U1, the dynamics of these three icy asteroids and a large number of hypothetical MBCs were studied. Results of extensive numerical integrations of these objects suggest that they were formed in place through the collisional breakup of a ...
openaire   +2 more sources

Alternative Policy Designs to Help Farmers Select Profitable Conservation Practices

Agribusiness, EarlyView.
ABSTRACT Voluntary private carbon initiatives (VPCIs) promote the implementation of agricultural conservation practices that mitigate emissions of greenhouse gases (GHGs) via financial incentives to participating farmers. Simultaneously, an array of public policies supports the adoption of conservation practices through technical and financial ...
Oranuch Wongpiyabovorn, Alejandro Plastina   +1 more
wiley   +1 more source

Gauss-Radau Small-body Simulator (GRSS): An Open-source Library for Planetary Defense

The Planetary Science Journal
We present GRSS , a small-body propagation and orbit determination library specifically designed for planetary defense applications. GRSS is an end-to-end, open-source software tool that begins with optical observations obtained from the Minor Planet ...
Rahil Makadia, Davide Farnocchia, Steven R. Chesley, Siegfried Eggl   +3 more
doaj   +1 more source

Selenium Nanomaterials for Wound Healing: Synergistic Strategies from Anti‐Infection to Tissue Regeneration

Advanced NanoBiomed Research, EarlyView.
Selenium nanoparticles (SeNPs) are emerging as multifunctional platforms for wound healing, integrating antimicrobial, anti‐inflammatory, and proregenerative activities. This review summarises key mechanisms and recent advances in SeNP‐enabled composite dressings, immunomodulatory nanocomposites, microenvironment‐responsive hydrogels, photothermal and ...
Yangxia Chen, Xiaoshuang Liang, Sirui Li, Shuoshan Li, Wei Liu, Yingping Lin, Siqi Li, Zehang Zhang, Judun Zheng, Tianfeng Chen, Rongyi Chen   +10 more
wiley   +1 more source