Results 51 to 60 of about 3,231,447 (290)

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

open access: yesAdvanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng   +9 more
wiley   +1 more source

Monitoring Cometary Activity of 60P/Tsuchinshan During Its 2018–2019 Apparition

open access: yesThe Astrophysical Journal, 2023
Comet 60P/Tsuchinshan is a Jupiter family comet. Since the discovery of 60P/Tsuchinshan, little research for cometary activity has been conducted on this comet, though it has returned to perihelion several times.
Jianchun Shi   +6 more
doaj   +1 more source

TESS-CoMET

open access: yes, 2018
R script to calculate CoMET function in ...
Guillermo Ortí (69121)   +9 more
core   +1 more source

ICOS‐ImmunoPET Monitors T Cell Activation After Combination Immune Checkpoint Blockade in a Mouse Model of Melanoma Brain Metastasis

open access: yesAdvanced Science, EarlyView.
ICOS‐immunoPET noninvasively visualizes activated T cells in melanoma brain metastases following combined anti‐PD‐1/anti‐CTLA‐4 therapy. Clinical translation of this imaging approach may improve patient stratification and treatment monitoring and serve as a quantitative imaging endpoint to support immunotherapy development and clinical trials in brain ...
Renesmee C. Kuo   +10 more
wiley   +1 more source

Comet 108P/Ciffreo: The Blob

open access: yesThe Astronomical Journal, 2023
Short-period comet 108P/Ciffreo is known for its peculiar double morphology, in which the nucleus is accompanied by a comoving, detached, diffuse “blob.” We report new observations of 108P/Ciffreo taken with the Hubble Space Telescope and the Nordic ...
Yoonyoung Kim   +4 more
doaj   +1 more source

comet-utilities: MS Thesis Release

open access: yes, 2015
<p>This Release includes all the required material for Matias Giorgio's MS Thesis: COMET Analyzer, RabbitMQ-to-MongoDB bridge, and other modules.</p ...
Matias Giorgio
core   +1 more source

Programming Gut Microbiome Function Through Cross‐Feeding: From Ecological Mechanisms to Live Biotherapeutics

open access: yesAdvanced Science, EarlyView.
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun   +7 more
wiley   +1 more source

The First Quantitative Study of Cometary Tail Regrowth following a Coronal Mass Ejection-driven Disconnection Event

open access: yesThe Astrophysical Journal
Comet C/2023 P1 (Nishimura) was observed by the Solar Orbiter Heliospheric Imager (SoloHI), on board the Solar Orbiter spacecraft, from 2023 September 1 to 14.
Shaheda Begum Shaik   +5 more
doaj   +1 more source

Dynamical constraints on the origin of Main Belt comets [PDF]

open access: yesMeteoritics & Planetary Science, 2009
Abstract— In an effort to understand the origin of Main Belt comets (MBCs) 7968 Elst‐Pizzaro, 118401, and P/2005 U1, the dynamics of these three icy asteroids and a large number of hypothetical MBCs were studied. Results of extensive numerical integrations of these objects suggest that they were formed in place through the collisional breakup of a ...
openaire   +2 more sources

On the Early Thermal Processing of Planetesimals during and after the Giant Planet Instability

open access: yesThe Planetary Science Journal
Born as ice-rich planetesimals, cometary nuclei were gravitationally scattered onto their current orbits in the Kuiper Belt and the Oort Cloud during the giant planets’ dynamical instability in the early stages of our solar system’s history.
Anastasios Gkotsinas   +4 more
doaj   +1 more source

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