Results 31 to 40 of about 7,430 (235)
Advanced Science, EarlyView.This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He +10 more
wiley +1 more source
Recurrent Cometary Activity Discovered on Quasi-Hilda Jupiter Family Comet 362P/(457175) 2008 GO98
The Astrophysical Journal LettersWe report the discovery of recurrent activity on quasi-Hilda comet (QHC) 362P/(457175) 2008 GO _98 . The first activity epoch was discovered during the perihelion passage of 362P in 2016, so we were motivated to observe it for recurrent cometary activity
Kennedy A. Farrell +7 more
doaj +1 more source
The Astronomical Journal, 2023 Short-period comet 108P/Ciffreo is known for its peculiar double morphology, in which the nucleus is accompanied by a comoving, detached, diffuse “blob.” We report new observations of 108P/Ciffreo taken with the Hubble Space Telescope and the Nordic ...
Yoonyoung Kim +4 more
doaj +1 more source
Advanced Science, EarlyView.PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang +10 more
wiley +1 more source
Interstellar Object 3I/ATLAS Observed from Mars by China’s Tianwen-1 Spacecraft
The Astrophysical Journal LettersChina’s Tianwen-1 Mars orbiter successfully imaged the third interstellar object, 3I/ATLAS, during its close encounter with Mars using the onboard HiRIC CMOS camera. This is China’s first deep-space observation of an astronomical object.
Xin Ren +22 more
doaj +1 more source
Advanced Science, EarlyView.Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu +9 more
wiley +1 more source
Monitoring Cometary Activity of 60P/Tsuchinshan During Its 2018–2019 Apparition
The Astrophysical Journal, 2023 Comet 60P/Tsuchinshan is a Jupiter family comet. Since the discovery of 60P/Tsuchinshan, little research for cometary activity has been conducted on this comet, though it has returned to perihelion several times.
Jianchun Shi +6 more
doaj +1 more source
Advanced Science, EarlyView.Conventional single‐gradient freeze‐casting typically produces unidirectional porous architectures with limited transverse connectivity. The Sequential Hybridization by Infiltration and Freeze‐casting Technique (SHIFT) addresses this constraint by integrating secondary aligned structures within a preformed primary scaffold.
Kiho Sung, Sungchul Shin
wiley +1 more source
Analysis of CN Coma Morphology Features of Comet 21P/Giacobini–Zinner
The Planetary Science Journal, 2023 We analyze jet features found in the coma of comet 21P/Giacobini–Zinner (21P/GZ) during its 2018 perihelion passage using narrowband CN photometric imaging in order to determine the comet’s rotational period, and we constrain the CN gas outflow velocity ...
Charles Goldberg +2 more
doaj +1 more source
Advanced Science, EarlyView.USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen +7 more
wiley +1 more source