Results 11 to 20 of about 3,411,943 (277)

MPP8 Facilitates DNA DSB Repair via NHEJ to Promote Chemoresistance of TNBC Independent of Methyl‐H3K9 Binding [PDF]

Advanced Science, EarlyView.
Chemoresistance is often linked to elevated DNA repair. MPP8 is found to promote breast cancer chemoresistance as a novel NHEJ accessory factor independent of its epigenetic functions. Through multiple protein interactions, MPP8 facilitates association of DNAPK and ligase complexes to promote DNA repair progression.
Rupa Kumari, Jia Fang
wiley   +2 more sources

Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation [PDF]

Advanced Science, EarlyView.
Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu, Jialu Kang, Qi Ye, Zixi Wang, Lei Li, Yuzeshi Lei, Leihong Ye, Tianjie Liu, Bin Wang, Tao Liu, Shan Xu, Ke Wang, Yong Zhang, Jian Ma, Lei Li   +14 more
wiley   +2 more sources

COMET-LF: a compartmental model of dynamics of infection, disease, and elimination strategies for lymphatic filariasis [PDF]

BMC Infectious Diseases
Background Lymphatic filariasis (LF) is a mosquito-borne disease caused by filarial worms. The WHO has targeted LF elimination by 2030. Mathematical models can help evaluate and guide elimination strategies. Methods We developed a new compartmental model—
Indrajit Ghosh, Suchita Nath-Sain, Shoummo Sen Gupta, Chhavi Pant Joshi, Tanu Jain, Swaminathan Subramanian, Souvik Banerjee, Mithun K. Mitra   +7 more
doaj   +2 more sources

Comet assay and antioxidant enzyme as blood biomarkers of low-dose radiation-induced adaptive response [PDF]

Scientific Reports
This study investigated the ability of low doses to cause an in vivo radio-adaptive response (RAR) and examined the biological effects of acute low-dose total-body gamma irradiation in rats. Adult male rats were randomly divided into 8 groups.
Misara M. Awad, Ahmed A. Abdelrahman, Ahmed A. Abdel-Aal, Ibrahim M. Hassan, Seham M. El-Marakby   +4 more
doaj   +2 more sources

Electron dynamics near diamagnetic regions of comet 67P/Churyumov- Gerasimenko [PDF]

, 2020
The Rosetta spacecraft detected transient and sporadic diamagnetic regions around comet 67P/Churyumov-Gerasimenko. In this paper we present a statistical analysis of bulk and suprathermal electron dynamics, as well as a case study of suprathermal ...
Nemeth, Z, Mokashi, P., Eriksson, A.I., Galand, M, Mokashi, P, Goldstein, R, Richter, I., Burch, JL, Galand, M., Burch, J.L., Cravens, T.E., Goldstein, R., Vigren, E, Cravens, TE, Madanian, H, Eriksson, AI, Richter, I, Rubin, M, Vigren, E., Nemeth, Z., Rubin, M., Madanian, H., Richter, I,, Nemeth, Z.,, Madanian, H.,, Rubin, M.,, Galand, M.,, Burch, J. L.,, Goldstein, R.,, Vigren, Erik,, Eriksson, A. , I, Mokashi, P.,, Cravens, T. E.,   +32 more
core   +4 more sources

Anti-migratory effect of vinflunine in endothelial and glioblastoma cells is associated with changes in EB1 C-terminal detyrosinated/tyrosinated status. [PDF]

PLoS ONE, 2013
We previously showed that vinflunine, a microtubule-targeting drug of the Vinca-alkaloid family exerted its anti-angiogenic/anti-migratory activities through an increase in microtubule dynamics and an inhibition of microtubule targeting to adhesion sites.
Amandine Rovini, Géraldine Gauthier, Raphaël Bergès, Anna Kruczynski, Diane Braguer, Stéphane Honoré   +5 more
doaj   +1 more source

X-Ray Emission Spectroscopy Analysis for Near-Asteroid Belt of Atmospheric of the Comets

Iraqi Journal of Physics, 2022
         According to Chandra Survey Observatory Near-Asteroid Belt Comets, the solar wind's contact with the comet produces a variety of spectral characteristics. The study of X-ray spectra produced by charge exchange is presented here. The spectrum of
Rasha S. Najm, Salman Z. Khalaf, Khaleel I. Abood   +2 more
doaj   +1 more source

Measuring Physical Properties at the Surface of a Comet Nucleus [PDF]

, 2021
The European Space Agency’s cornerstone mission Rosetta is due for launch in January 2003. It will perform a rendezvous with comet 46P/Wirtanen beyond 3 AU and, following an initial mapping phase, deploy a lander to a selected site on the nucleus surface.
Ball, Andrew Jonathan, Ball, Andrew J.
core   +1 more source

ASSIST: An Ephemeris-quality Test-particle Integrator

The Planetary Science Journal, 2023
We introduce ASSIST, a software package for ephemeris-quality integrations of test particles. ASSIST is an extension of the REBOUND framework and makes use of its IAS15 integrator to integrate test-particle trajectories in the field of the Sun, Moon ...
Matthew J. Holman, Arya Akmal, Davide Farnocchia, Hanno Rein, Matthew J. Payne, Robert Weryk, Daniel Tamayo, David M. Hernandez   +7 more
doaj   +1 more source

Stochastic modeling for the COMET-assay [PDF]

, 2003
We present a stochastic model for single cell gel electrophoresis (COMET-assay) data. Essential is the use of point process structures, renewal theory and reduction to intensity histograms for further data ...
Hösel, V., Boulesteix, Anne-Laure, Hösel, Volker, Liebscher, Volkmar, Liebscher, V.   +4 more
core   +1 more source