Results 41 to 50 of about 8,464 (293)
Advanced Science, EarlyView.Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang +11 more
wiley +1 more source
Interstellar Object 3I/ATLAS Observed from Mars by China’s Tianwen-1 Spacecraft
The Astrophysical Journal LettersChina’s Tianwen-1 Mars orbiter successfully imaged the third interstellar object, 3I/ATLAS, during its close encounter with Mars using the onboard HiRIC CMOS camera. This is China’s first deep-space observation of an astronomical object.
Xin Ren +22 more
doaj +1 more source
Monitoring Cometary Activity of 60P/Tsuchinshan During Its 2018–2019 Apparition
The Astrophysical Journal, 2023 Comet 60P/Tsuchinshan is a Jupiter family comet. Since the discovery of 60P/Tsuchinshan, little research for cometary activity has been conducted on this comet, though it has returned to perihelion several times.
Jianchun Shi +6 more
doaj +1 more source
Macrophage Extracellular Traps in Immunity and Cancer
Advanced Science, EarlyView.As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li +5 more
wiley +1 more source
Modeled Interaction of Comet 67P/Churyumov-Gerasimenko with the Solar Wind Inside 2 AU [PDF]
, 2015 Periodic comets move around the Sun on elliptical orbits. As such comet 67P/Churyumov-Gerasimenko (hereafter 67P) spends a portion of time in the inner solar system where it is exposed to increased solar insolation.
K. C. Hansen +13 more
core +1 more source
Analysis of CN Coma Morphology Features of Comet 21P/Giacobini–Zinner
The Planetary Science Journal, 2023 We analyze jet features found in the coma of comet 21P/Giacobini–Zinner (21P/GZ) during its 2018 perihelion passage using narrowband CN photometric imaging in order to determine the comet’s rotational period, and we constrain the CN gas outflow velocity ...
Charles Goldberg +2 more
doaj +1 more source
Advanced Science, EarlyView.This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He +10 more
wiley +1 more source
Advanced Science, EarlyView.This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy +16 more
wiley +1 more source
The Astrophysical JournalComet C/2023 P1 (Nishimura) was observed by the Solar Orbiter Heliospheric Imager (SoloHI), on board the Solar Orbiter spacecraft, from 2023 September 1 to 14.
Shaheda Begum Shaik +5 more
doaj +1 more source
MIR Spectra and Analysis of Jovian Trojan Asteroids
The Planetary Science Journal, 2023 Jovian Trojan asteroids make up a large group of primitive bodies that populate Jupiter's L4 and L5 Lagrange points. The Trojans’ dynamics and composition carry insight into the formation mechanisms that shaped our solar system. Mid-infrared (MIR; 5–35 μ
Audrey C. Martin, Joshua P. Emery
doaj +1 more source