Results 201 to 210 of about 2,103,717 (319)

Multi‐Stage Shallow Rupture and Pre‐Event Shallow Deformation During the 2025 Mw 5.9 Asadabad Earthquake (Afghanistan)

Geophysical Research Letters, Volume 53, Issue 9, 16 May 2026.
Abstract The 31 August 2025 Mw 5.9 Asadabad earthquake in eastern Afghanistan caused severe damage despite its moderate magnitude, raising questions about rupture processes and seismic hazard in the southern Hindu Kush. Using Sentinel‐1 InSAR and teleseismic waveform modeling, we reveal a complex, multi‐stage shallow (4–5 km) rupture involving the ...
Ping He, Timothy J. Craig, Yangmao Wen, Huihui Weng, Kefeng He, Caijun Xu   +5 more
wiley   +1 more source

β3 accelerates microtubule plus end maturation through a divergent lateral interface. [PDF]

Mol Biol Cell
Wood LM, Moore JK.
europepmc   +1 more source

Synergistic Effects of DNA‐PKcs Inhibition and Radiotherapy in Esophageal Squamous Cell Carcinoma

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
Radiotherapy induces double‐strand DNA breaks in esophageal squamous cell carcinoma, triggering DNA‐PKcs phosphorylation and activating the non‐homologous end joining (NHEJ) repair pathway, which contributes to radioresistance. Inhibiting DNA‐PKcs disrupts this repair mechanism, enhancing radiosensitivity by blocking NHEJ, amplifying DNA damage, and ...
Jiekun Qian, Guoliang Liao, Jianting Du, Maojie Pan, Maohui Chen, Long Wu, Xin Yan, Chun Chen, Bin Zheng, Zhang Yang   +9 more
wiley   +1 more source

Multiple formation pathways for amino acids in the early Solar System based on carbon and nitrogen isotopes in asteroid Bennu samples. [PDF]

Proc Natl Acad Sci U S A
Baczynski AA, Mcintosh OM, Simkus DN, McLain HL, Dworkin JP, Glavin DP, Elsila JE, Matney M, House CH, Freeman KH, Connolly HC, Lauretta DS.   +11 more
europepmc   +1 more source

Origin and Formation of Comets [PDF]

Nature, 1949
openaire   +1 more source

Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase

Cell Cycle, 2010
S. Mcneely, C. Conti, Tahir N. Sheikh, Himali Patel, S. Zabludoff, Y. Pommier, G. Schwartz, A. Tse   +7 more
semanticscholar   +1 more source

Effects of Intermittent Fasting‐Mimicking Diet on Pancreatic Islet Plasticity: Immunohistochemical, Ultrastructural, and Metabolic Profiles

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
Three weeks of fasting‐mimicking diet in female C57BL/6J mice increased pancreatic BNR4+ cells, PDX1+BRN4+ cells and insulin+glucagon+ cells after fasting in fluorescent multiplexed immunohistochemistry. Mice showed impaired glucose tolerance after fasting but not after refeeding after 2 weeks.
Clemens M. Harer, Beate Boulgaropoulos, Barbara Ehall, Lea Bogensperger, Kaddour Bounab, Dominique Pernitsch, Joakim Franz, Laurin Herbsthofer, Petra Kotzbeck, Jelena Krstic, Andreas Prokesch, Barbara Prietl, Dagmar Kolb, Thomas R. Pieber   +13 more
wiley   +1 more source

EP300 deficiency leads to chronic replication stress mediated by defective replication fork protection. [PDF]

Nat Commun
Barreto-Galvez A, Niljikar M, Gagliardi JE, Guzman CP, Zhang R, Kumar V, Juwarwala A, Pradeep A, Saxena A, Montagna C, Mittal P, Gerhardt J, Xia B, Cao J, Kataoka K, Durbin AD, Qi J, Ye BH, Madireddy A.   +18 more
europepmc   +1 more source

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, Volume 13, Issue 25, 4 May 2026.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source