Results 51 to 60 of about 53,221 (292)

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, EarlyView.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

Fabry's Comet and Barnard's Comet [PDF]

Nature, 1886
NOT having seen any mention of the rapid apparent growth of the tail of Fabry's comet, probably some of your readers are not aware to how great a length it extended. On April 26 occurred the first fine night after a very unusual series of overcast ones, and about 14h. G.M.T. I was surprised to see the tail reaching up to, or at least to within 1° of δ,
openaire   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

Brightness Behavior of Distant Oort Cloud Comets

The Planetary Science Journal
Dynamically new comets provide important insights into the conditions of the presolar nebula and its evolution, as they are believed to have experienced minimal solar heating before their discovery.
Carrie E. Holt, Matthew M. Knight, Michael S. P. Kelley, Tim Lister, Quanzhi Ye, Colin Snodgrass, Cyrielle Opitom, Rosita Kokotanekova, Megan E. Schwamb, Matthew M. Dobson, Michele T. Bannister, Marco Micheli, Stefanie N. Milam, Derek C. Richardson, The LCO Outbursting Objects Key (LOOK) Project, Edward Gomez, Joseph P. Chatelain, Sarah Greenstreet   +17 more
doaj   +1 more source

Low YTHDC1 Expression Upregulates FSCN1 to Promote Nuclear F‐Actin Formation and Facilitate Double‐strand DNA Breaks Repair in TMZ‐Resistant Glioblastoma

Advanced Science, EarlyView.
This study revealed that low expression of YTHDC1 in TMZ‐resistant GBM cells leads to increased FSCN1 expression, which is suppressed by m6A modification. FSCN1 activates the CDC42/N‐WASP/Arp2/3 axis in the cell nucleus by recruiting the guanine nucleotide exchange factor (GEF) family member FGD1, thereby promoting F‐actin polymerization in the nucleus.
Minglong Yang, Wanxiang Niu, Yuanfei Wang, Peng Chen, Maolin Mu, Xiaoming Zhang, Ben Xu, Shanshan Hu, Chaoshi Niu, Pengfei Wu   +9 more
wiley   +1 more source

Thermal Evolution of the Nucleus of the Comet 67P for 120 Years: Numerical Simulations

Open Astronomy, 2018
The purpose of this paper is to estimate to what temperatures and to what depth the outer layers of the cometary nuclei are heated for several dozen revolutions around the Sun, and what changes in the composition of the volatiles occur in this case. This
Rusol Andrey V., Dorofeeva Vera A.
doaj   +1 more source

COMET: Coverage-guided Model Generation For Deep Learning Library Testing [PDF]

, 2022
Meiziniu Li, Jialun Cao, Yongqiang Tian, Tsz On Li, Ming Wen, Shing-Chi Cheung   +5 more
openalex   +1 more source

Principles for Rigorous Design and Application of Synthetic Microbial Communities

Advanced Science, EarlyView.
SynComs are artificially designed to enable inter‐species metabolic interactions, metabolic division of labor, and ecological interactions that can elicit phenotypes like colonization stability and environmental adaptation. This systematic review explores the processes used to construct SynComs, the assessment of the mechanisms of metabolic interaction
Yuxiao Zhang, Minyu Jing, Lihui Lyu, Li Nie, Xihui Xu, Ru Sun, Xiyuan Xu, Siyu Chen, Shuobing He, Yumeng Zhang, Ping Huang, Weijie Luo, Jiaojiao Liang, Guifeng Gao, Kunkun Fan, Teng Yang, Liyan Zhang, Xiao Fu, Sarah M. Allard, Jack A. Gilbert, Jiabao Zhang, Haiyan Chu   +21 more
wiley   +1 more source

Photoluminescence and Cathodoluminescence of the Solid Cometary Substance

Open Astronomy, 2019
We have proposed that solar ultraviolet and corpuscular radiations may excite photoluminescence and cathodoluminescence of the solid cometary substance including mineral halos of comets.
Simonia Irakli, Gucsik Arnold
doaj   +1 more source

Chloroplast Stress Signals Orchestrate Epidermis‐Specific Remodeling of Mitochondria and ER Under High Light

Advanced Science, EarlyView.
High light exposure triggers an epidermis‐specific remodeling of mitochondria and ER in Arabidopsis, driven by chloroplast‐derived signals. Live‐cell imaging shows that HL rapidly suppresses mitochondrial motility, followed by fusion‐driven elongation and ER cisternal expansion.
Evan R. Angelos, Hee‐Seung Choi, Jingzhe Guo, Andrea A. Zanini, Tessa M. Burch‐Smith, Emily Snyder, Matthew Part, Wilhelmina van de Ven, Manhoi Hur, Gerd Ulrich Balcke, Alain Tissier, Quanqing Zhang, Katayoon Dehesh   +12 more
wiley   +1 more source