Results 71 to 80 of about 8,090 (243)
Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning
Cytoskeleton, EarlyView.ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham +3 more
wiley +1 more source
Cancer Nexus, EarlyView.ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han +5 more
wiley +1 more source
Navigating the Genetic Risk of Chemotherapy‐Induced Hearing Loss in the Stria Vascularis
Clinical Pharmacology &Therapeutics, EarlyView.Cisplatin is a chemotherapy drug that causes permanent hearing loss by damaging a critical tissue lining the inner ear, called the stria vascularis (SV). Currently, the molecular mechanisms of SV damage are largely unknown and the incidence of ototoxicity in patients cannot be reliably predicted.
Tara Lazetic +4 more
wiley +1 more source
Open Astronomy, 2015 We cast a retrospective look at the mankind’s acquaintance with minor bodies of the Solar System, at the explosive growth in their discoveries resulting from the technological progress, and at gradual understanding of the danger to our very existence ...
Rykhlova L., Bakanas E.
doaj +1 more source
Machine Learning Approaches for GC–MS Data Interpretation in Flavour and Fragrance Analysis
Flavour and Fragrance Journal, EarlyView.The review explores machine learning integration in GC‐MS data analysis for the fragrance and flavour industry, highlighting recent advances and techniques in a context constrained by data scarcity and intellectual property concerns. ABSTRACT This review explores the integration of machine learning (ML) in the analysis of mass spectrometry data ...
Jean‐Baptiste Coffin +3 more
wiley +1 more source
International Journal of Cancer, EarlyView.What's New? Errors in DNA double‐strand break (DSB) repair can lead to mutations, chromosomal instability, and ultimately cancer. Inhibitor of DNA‐binding 3 (ID3), a transcriptional repressor, is crucial to promoting DSB repair and helping maintain genome stability. Here, the authors investigated ID3 regulation of DNA repair via chromatin accessibility
Giuditta Della Corte +10 more
wiley +1 more source
iMetaMed, EarlyView.Pyridoxal (PL) exhibits the strongest anti‐tumor activity within the vitamin B6 family, demonstrating significant ovarian cancer cell‐killing efficacy in vivo, in vitro, and in patient‐derived organoid (PDO) models. The anti‐tumor mechanism involves PL inducing a shift in peroxisome dynamics towards fission, promoting peroxisome proliferation, and ...
Ruonan Li +12 more
wiley +1 more source
The Impact of Genotoxicity in Coke Oven Workers: Systematic Review With Meta‐Analysis
Journal of Applied Toxicology, EarlyView.ABSTRACT This systematic review (SR) with meta‐analysis investigates the genotoxicity potential of coke oven workers (COWs) exposed to polycyclic aromatic hydrocarbons (PAHs) through a comprehensive analysis of studies retrieved from PubMed, SCOPUS, and Web of Science.
Thiago Guedes Pinto +7 more
wiley +1 more source
Izdelava digitalnih modelov reliefa planetov s poudarkom na klinometriji : The Production of Digital Elevation Models of Planets with an Emphasis on Clinometry [PDF]
Geodetski Vestnik, 2004 Four methods for extracting height data from photographs made with active or passive sensors are described: clinometry, stereometry, interferometry, and polarimetry. Clinometry is described in detail.
Mihaela Triglav Čekada
doaj