Results 31 to 40 of about 4,451 (299)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Commémorations, scandale et circulation de l’information : le Centenaire de la bataille de Verdun sur Twitter

open access: yesFrench Journal for Media Research, 2018
Le Centenaire de la Grande Guerre fait l’objet de nombreuses commémorations. Sur le réseau social numérique Twitter, des millions de tweets l’évoquent.
Clavert Frédéric
doaj  

El aula, entre la historia y la conmemoración. Reflexiones y propuestas para revisar efemérides decimonónicas desde el profesorado universitario en Historia

open access: yesClio y Asociados
In this paper, we propose to review some of the national commemorations thatbelong to the nineteenth century. Based on the experience of teaching a degree subject in the History Professorate of the Universidad Nacional de Mar del Plata, we intend to ...
María Laura Mazzoni   +1 more
doaj   +1 more source

Quand débute la Réforme en France ?

open access: yesEtudes Epistémè, 2017
31 October 1517 is traditionally taken as the starting point for the Reformation, even if the date is controversial. But the French Reformation has no easily identifiable starting date.
Yves Krumenacker
doaj   +1 more source

TRANSFORMATIVE HISTORY: AMERICAN MONUMENT-MAKING AND THE ROAD TO INCLUSIVE PUBLIC COMMEMORATIONS FOR BLACK AMERICAN VETERANS [PDF]

open access: yes, 2022
In this thesis, I survey American public commemorations about war, the military, and Black American veterans from the nineteenth century to the present.
Bendolph, Jeanette Dianne
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

La commémoration de l’histoire conflictuelle à l’aune de la Question Chypriote : réflexion sur les acteurs et les échelles des dispositifs commémoratifs

open access: yesL'Espace Politique, 2021
This article by a young researcher aims to analyse different phenomena of commemoration in Cyprus. Taking this divided country and society, we wish to highlight the specificity of commemorative territories and artefacts, such as memorials and museums in ...
Marie Pouillès Garonzi
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

A pacifist critique of the red poppy: reflections on British war commemorations’ increasingly hegemonic militarism

open access: yes, 2021
The red or ‘Flanders’ poppy has become the ubiquitous emblem of British war commemorations, yet it is also becoming more hegemonic and militaristic: the poppy’s meaning has always been contested, but its dominant interpretation has become increasingly ...
Alexandre Christoyannopoulos (1252407)
core   +1 more source

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