Results 51 to 60 of about 58,057 (392)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

La commémoration de l’histoire conflictuelle à l’aune de la Question Chypriote : réflexion sur les acteurs et les échelles des dispositifs commémoratifs

open access: yesL'Espace Politique, 2021
This article by a young researcher aims to analyse different phenomena of commemoration in Cyprus. Taking this divided country and society, we wish to highlight the specificity of commemorative territories and artefacts, such as memorials and museums in ...
Marie Pouillès Garonzi
doaj   +1 more source

The Yugoslav State Security Service and the Bleiburg Commemorations

open access: yesPolitička Misao, 2018
This article, based overwhelmingly on primary sources produced by the Yugoslav State Security Service, provides a historical overview of their work with respect to the commemorations at Bleiburg.
C. Nielsen
semanticscholar   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Smith\u27s Poetic Heroes: Literary Commemorations of Warriors and Warrior Culture in the Early Biblical World (Book Review)

open access: yes, 2016
A review of Smith, Mark S. Poetic Heroes: Literary Commemorations of Warriors and Warrior Culture in the Early Biblical World. Grand Rapids, MI: Eerdmans, 2014. xxiv1636 pp. $55.00 (paper)
Doak, Brian R.
core   +2 more sources

November 11 under two flags: a comparative analysis of officials’ speeches on World War I end commemorations in Poland and France

open access: yesŚwiat Idei i Polityki
The article compares dominant attitudes regarding November 11 in Poland and France. In both states, this date, which is related to the end of World War I and the restoration of the independence of Poland in 1918, constitutes a public holiday.
Bartłomiej Różycki, Geoffrey Lefebvre
doaj   +1 more source

Sanctifying Minority Status in the Himalayan \u3ci\u3eUmmah\u3c/i\u3e: Eid al-Ghadeer Commemorations among the Shia in Leh, Ladakh [PDF]

open access: yes, 2018
Drawing on ethnographic data, this article argues that the Shia in Leh, Ladakh employ religious ceremonies such as Eid al-Ghadeer to construct a sense of sacred community and a sanctified minority status within the Himalayan ummah.
Singh, Rohit
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

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