Results 21 to 30 of about 403,994 (268)

Prawne aspekty twórczości commentary

open access: yesOpolskie Studia Administracyjno-Prawne, 2022
Twórczość commentary jest jednym z obecnych trendów w polskim Internecie. Coraz więcej internautów rozpoczyna swoja przygodę z tworzeniem materiałów komentujących, omawiających, a czasem i piętnujących zachowania innych użytkowników Internetu – zwłaszcza
Dominik Gabor
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

How to become a successful researcher: tips for early career researchers

open access: yesScandinavian Journal of Work, Environment & Health, 2014
Academia is a world on its own with many hidden rules that can be confusing for early career researchers (ECR). Moreover, research is highly competitive. A young scientist pursuing an academic career faces a future of writing applications for fellowships
Susan Peters
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Konstantin Bolshakov in military service: Revisiting the issue [PDF]

open access: yesЛитературный факт, 2019
The note provides a clarifying commentary on the final part of V.I. Mozalevsky’s memoirs “Paths, ways, encounters”. The commentary concerns the Russian poet and prose writer Konstantin Aristarkhovich Bolshakov (1895– 1938) and the details associated with
Nikolay Bogomolov
doaj   +1 more source

TREX1, a predator for treating MSI‐H tumors?

open access: yesMolecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya   +2 more
wiley   +1 more source

Update

open access: yesWorld Nutrition, 2014
The Oslo-Lancet report: global health governance and food security The new Brazilian dietary guide emphasises enjoyment of meals Weston Price, TL Cleave, John Yudkin, the sugar pioneers The real cost of meat.
Commentary team
doaj  

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

open access: yesMolecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti   +3 more
wiley   +1 more source

Mulomedicina Chironis 3-15 (la pratica del salasso). Testo critico, traduzione e commento

open access: yesPallas, 2020
Paragraphs 3-15 (concerning the bloodletting of the horse) of the so-called Mulomedicina Chironis are here critically published. An Italian translation and a commentary follow.
Vincenzo Ortoleva
doaj   +1 more source

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