Results 21 to 30 of about 233,273 (241)

Müfessir Fahreddin er-Râzî’nin Meteorolojik Olaylarla İlgili Âyetlere Yaklaşımı

open access: yesEskiyeni, 2020
Kur’an, insanlık için bir rehber ve hidayet kaynağı olarak indirilmiş, açık ve anlaşılır bir ilâhî kitap-tır. İndirildiğinden bugüne onun en doğru şekilde anlaşılması, tefsir ilminin ana konusunu oluş-turur.
Abdulkadir Demir
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Prawne aspekty twórczości commentary

open access: yesOpolskie Studia Administracyjno-Prawne, 2022
Twórczość commentary jest jednym z obecnych trendów w polskim Internecie. Coraz więcej internautów rozpoczyna swoja przygodę z tworzeniem materiałów komentujących, omawiających, a czasem i piętnujących zachowania innych użytkowników Internetu – zwłaszcza
Dominik Gabor
doaj   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

open access: yesMolecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti   +3 more
wiley   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga   +2 more
wiley   +1 more source

How to become a successful researcher: tips for early career researchers

open access: yesScandinavian Journal of Work, Environment & Health, 2014
Academia is a world on its own with many hidden rules that can be confusing for early career researchers (ECR). Moreover, research is highly competitive. A young scientist pursuing an academic career faces a future of writing applications for fellowships
Susan Peters
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Konstantin Bolshakov in military service: Revisiting the issue [PDF]

open access: yesЛитературный факт, 2019
The note provides a clarifying commentary on the final part of V.I. Mozalevsky’s memoirs “Paths, ways, encounters”. The commentary concerns the Russian poet and prose writer Konstantin Aristarkhovich Bolshakov (1895– 1938) and the details associated with
Nikolay Bogomolov
doaj   +1 more source

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