Results 31 to 40 of about 403,994 (268)
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
İlahiyat AkademiKıraat ilminin hiç şüphesiz üstlenmiş olduğu ve titizlikle yerine getirdiği en büyük görev, sahih kıraatleri sahih olmayan kıraatlerden ayırarak ilahi vahiy olan Kur’ân-ı Kerîm’in kelime ve telaffuzlarının günümüze kadar korunarak gelmesini sağlamaktır ...
Mustafa Aksoy
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Greek tragedians in ancient and medieval Armenia
Шаги1. А Greek inscription found in Armavir (Armenia) written probably in the 2nd c. BC in a script close to papyrus cursive, contains a fragment from a tragedy similar in style to Euripides. 2. Plutarch writes that the Armenian king Artavazd (Artavasdes) II
G. S. Muradyan
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Scandinavian Journal of Work, Environment & Health, 2012 Andersen et al (1) recently published data from a study on brief daily exercise and headache. They reported that a 10-week intervention with 2 minutes of daily exercise using an elastic tube caused a decrease in headache frequency from 1.4 to 0.9 days ...
Johan H Andersen, Sigurd Mikkelsen
doaj +1 more source
Journal of Interactive Media in Education, 2004 : This chapter presents some elegant ideas about how an individual institution can manage its online content to promote repurposing and re-use. The cases illustrate the benefits and issues involved in making this work.
Tom Carey, Kevin Harrigan
doaj +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
The placebo effect revisited – author response
Scandinavian Journal of Work, Environment & Health, 2012 Our randomized controlled trial showed a reduction of neck/shoulder pain and headache in response to 10 weeks of resistance training performed for 2 minutes a day (1, 2).
Lars L Andersen
doaj +1 more source