Results 51 to 60 of about 876,625 (302)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
ACEPTACIÓN DEL E-COMMERCE EN COLOMBIA: UN ESTUDIO PARA LA CIUDAD DE MEDELLÍN
Revista Facultad de Ciencias Económicas, 2011 El e-Commerce es un fenómeno creciente en Latinoamérica y Colombia por lo que el estudio de su aceptación tecnológica es de alta importancia académica y empresarial. El objetivo de este artículo es identificar los antecedentes de la intención de uso de e-
JUAN F. TAVERA MESÍAS +2 more
doaj
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
CONCEPTUAL ASPECTS REGARDING SYSTEMIC TREATMENT OF COMMERCIAL MANAGEMENT OF AGRI-FOOD PRODUCTS [PDF]
Economica, 2017 Trade is of strategic importance for the balanced and viable development of economic and social systems in a country. And the management development of an organization's commercial activity is the main vector of business success.
Tatiana DIACONU +2 more
doaj
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
, 2016 "Jan. 20, 2015" [i.e. 2016]. Includes a screenshot of the "New Kansas Commerce Website" and a copy of the December 2015 issue of the Kansas Commerce Newsletter.; Information provided to the Kansas Legislature, Senate Commerce Committee, by Antonio J ...
Soave, Antonio J., J.D.
core +1 more source
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source