Results 101 to 110 of about 952,996 (308)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Multiple linear regression to predict carcass tissue composition in hair lambs raised under commercial system

Revista Científica
The aim of the present study was to predict the carcass tissue composition of hair lambs reared on a commercial system, based on the characteristics of commercial cuts using multiple linear regression. In the study, thirty crossbred male lambs (Pelibuey
Rodrigo Portillo-Salgado, Juan Escobedo-Canul, Dany Alejandro Dzib-Cauich, Ángel Carmelo Sierra-Vásquez, Emilio Pérez-Pacheco, Víctor Manuel Moo-Huchin, Alfonso Juventino Chay-Canul, Raciel Javier Estrada-León   +7 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

The proinsulin content of commercial bovine insulin formulations

Journal of Pharmacy and Pharmacology, 1984
Abstract The proinsulin-like immunoreactivity (PLI) content of traditional and highly purified bovine insulin preparations sold by three insulin manufacturers in the UK has been estimated by radioimmunoassay. We report the PLI content of 22 batches of traditional insulin products and 32 of highly purified insulin, marketed between March ...
N, Sutcliffe, A F, Bristow
openaire   +2 more sources

Future scenarios of commercial internet content delivery [PDF]

, 2012
The Internet content volume is growing rapidly. As a consequence, the current Internet model struggles with scalability and usability requirements.
Zhang, Nan, Levä, Tapio, Hämmäinen, Heikki   +2 more
core  

Analysis on the Chlorophyll Content of Commercial Green Leafy Vegetables

, 2015
The objectives of the present study were to evaluate the chlorophyll content of green leafy vegetables found commercially and carry out a comparative investigation between in vivo and in vitro data. The chlorophyll of green leafy vegetable can be used as
Limantara, Leenawaty, Brotosudarmo, Tatas Hardo Panintingjati, Dettling, Martin, Indrawati, Renny, Indriatmoko,   +4 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Mapping carcass and meat quality QTL on Sus Scrofa chromosome 2 in commercial finishing pigs

, 2009
Quantitative trait loci (QTL) affecting carcass and meat quality located on SSC2 were identified using variance component methods. A large number of traits involved in meat and carcass quality was detected in a commercial crossbred population: 1855 pigs ...
Knol, A.J., Bovenhuis, H., Egbert F Knol, Bovenhuis Henk, Knol, E.F., Heuven, H.C.M., van Kampen, T.A., Bert Dibbits, Kampen, A.J.A., van, van Wijk, R.H.J., Henk Bovenhuis, van Kampen, A.J.A., Dibbits, B.W., Dibbits, B., Henri CM Heuven, van Wijk, H.J., Knol Egbert F, Tony A van Kampen, Dibbits Bert, van Wijk Rik HJ, Rik HJ van Wijk, Wijk, H.J., van, Heuven Henri CM, van Kampen Tony A   +23 more
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source