Results 91 to 100 of about 2,977,823 (259)

Mechanism Design with Limited Commitment [PDF]

open access: yes, 2020
We develop a tool akin to the revelation principle for mechanism design with limited commitment. We identify a canonical class of mechanisms rich enough to replicate the payoffs of any equilibrium in a mechanism-selection game between an uninformed ...
Doval, Laura, Skreta, Vasiliki
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Time and commitment: the grammaticalization of uúch in Lakandon Maya

open access: yesJournal de la Société des Américanistes, 2017
The paper accounts for the grammaticalization of uúch, (‘previously’, ‘long ago’) from a one-place predicate in Yukatek Maya meaning ‘to happen’, to a cognate adverbial in Lakandon Maya denoting ‘knowledge asymmetry’; a change from subjective ‘time’ to ...
Henrik Bergqvist
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Commitment to Development Index 2014 [PDF]

open access: yes, 2014
In this report, The Commitment to Development Index ranks 27 of the world's richest countries on their policies that affect more than five billion people living in poorer nations.
Owen Barder, Petra Krylová
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

L’expérience du politique dans le milieu associatif en Argentine : entre modes de vie, bénévolat et travail

open access: yesSociologies, 2017
In Argentine, there is renewed attention to civil society organizations both as a social policy device to solve unemployment and as a form of political commitment.
Pia V. Rius
doaj  

Crisis and Organizational Sustainability: Empirical Analysis of the Implication of Transformational Leadership on the Decision to Stay Mediated by the Commitment of the Democratic Party in Indonesia

open access: yesSocial Sciences
The research focuses on the impact of transformational leadership on the decision to stay mediated by commitment after a court refusal regarding illegal extraordinary congress involving the outsiders of a political party in Indonesia (in this case, it is
Herzaky Mahendra Putra   +5 more
doaj   +1 more source

A Practitioner’s Approach to Drucker’s Knowledge - Worker Productivity in the 21st Century: A New Model (Part One) [PDF]

open access: yesRevista de Management Comparat International, 2010
This article examines productivity in the context of the 21st century, focusing on Drucker’s prophecy of knowledge-worker productivity, the power of ‘unified strategy’, organisational interdependence and a practitioner’s approach to knowledge-worker ...
Peter S. WONG , Philip A. NECK
doaj  

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