Results 81 to 90 of about 7,321,229 (297)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Experimental investigation of the impact of optical injection on vital parameters of a gain-switched pulse source [PDF]

, 2007
An analysis of optical injection on a gain-switched distributed feedback (DFB) laser and its impact on pulse parameters that influence the performance of the pulse source in high-speed optical communication systems is presented in this paper.
Besnard, Pascal, Anandarajah, Prince M., Guignard, Celine, Barry, Liam P., Vaudel, O., Clarke, Aisling M., Clarke, Aisling, M., Vaudel, Olivier, Barry, Liam, P., Besnard, P., Anandarajah, Prince, M.   +10 more
core   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Common-mode suppression for balanced bandpass filters in multilayer liquid crystal polymer technology

, 2015
A new multilayer differential transmission line for common-mode suppression fabricated using an organic liquid crystal polymer multilayer substrate is proposed and analysed.
Martel, Jesus, Medina, Francisco, Naqui, Jordi, Martín, Ferran, Fernández-Prieto, Armando, Hong, Jiasheng, Mesa, Francisco, Qian, Shilong   +7 more
core   +1 more source

S-shaped complementary split ring resonators and their application to compact differential bandpass filters with common-mode suppression [PDF]

, 2014
This letter presents an S-shaped complementary split ring resonator (S-CSRR) for application in compact differential filters. The working principle of the proposed S-CSRR is explained and a circuit model is developed and validated through electromagnetic
Durán-Sindreu, Miguel, Karami-Horestani, Ali, Naqui, J., Karami Horestani, A., Martín, Ferran, Fumeaux, Cristophe, Duran-Sindreu, M., Fumeaux, C., Martin, F., Naqui Garolera, Jordi   +9 more
core   +1 more source

Shaft Voltage Suppression of Double-fed Generator for High Power Wind Turbine

Kongzhi Yu Xinxi Jishu, 2013
The mechanism and adverse effects of shaft voltage in double-fed generator generated by inverter is analyzed. As shaft voltage is part of common-mode voltage, a new LCL-filter of converter for suppression of common-mode voltage is proposed through ...
CAO Guorong, ZHAO Yanfeng, TANG Jianping, WANG Baogui, YUAN Ying, WANG Ying   +5 more
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Evaluation Method and Modeling Analysis of the Common Mode Noise Suppression Capability of Full-Bridge Transformers

The effective capacitance of the common mode port serves as a critical metric for assessing the common mode noise suppression capability of transformers in power converters.
Wei Chen, Yipeng Kong
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Hybrid EBG Structure for Common-Mode Noise and SSN Suppression in Multilayer PCBs

IEEE Access
The advancement of modern technologies and the growing demand for high-speed communication systems that integrate digital and analog circuits into multilayer printed circuit boards (PCBs) require the development of efficient solutions to ensure signal ...
Jean Carlos Bortoli Dalcin, Marlio Jose Do Couto Bonfim   +1 more
doaj   +1 more source