Results 51 to 60 of about 954,905 (286)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Poverty and the Environment: Exploring the Relationship between Household Incomes, Private Assets, and Natural Assets [PDF]
Using purpose-collected survey data from 537 households in 60 different villages of the Jhabua district of India, this paper investigates the extent to which rural households depend on common-pool natural resources for their daily livelihood.
Gupta, Shreekant +2 more
core +3 more sources
International Journal of the Commons, 2017 Research on common-pool resources in the last 30 years has hinged on concepts such as rules and property rights for understanding how access and use of natural resources is managed by communities and other actors.
Degu Tadie, Anke Fischer
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Commons management and ecotourism: Ethnographic evidence from the Amazon
International Journal of the Commons, 2009 The paper evaluates the relationship between ecotourism and commons management. Social and economic impacts of ecotourism in an indigenous village in the Peruvian Amazon are considered in relation to opportunities for collective action to manage common ...
Amanda Lee Stronza
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Understanding large social-ecological systems: introducing the SESMAD project
International Journal of the Commons, 2014 This article introduces the Social-ecological systems meta-analysis database (SESMAD) project, which is the project behind the case studies and synthetic articles contained in this special issue of the 'International Journal of the Commons'. SESMAD is an
Michael Cox
doaj +1 more source
Human Adaptive Behavior in Common Pool Resource Systems
PLoS ONE, 2012 Overexploitation of common-pool resources, resulting from uncooperative harvest behavior, is a major problem in many social-ecological systems. Feedbacks between user behavior and resource productivity induce non-linear dynamics in the harvest and the resource stock that complicate the understanding and the prediction of the co-evolutionary system ...
Gunnar Brandt +3 more
openaire +4 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Revue de Géographie Alpine, 2008 Common-pool resources are natural or man-made resources shared among different users, a condition that produces a competition for their utilization leading often (although not necessarily) to their degradation or even to their destruction.
Giangiacomo Bravo, Beatrice Marelli
doaj +1 more source