Results 61 to 70 of about 14,032,665 (282)

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A simulation function approach for optimization by approximate solutions with an application to fractional differential equation

Nonlinear Analysis
In this work, we study the existence and uniqueness of a common best proximity point for a pair of nonself functions that are not necessarily continuous using the simulation function.
Parvaneh Lo'lo', Maryam Shams, Stojan Radenović   +2 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Parallelism of the Occlusal Plane with the Ala-tragus Line in Various Posterior References in Dentate Patients

Journal of Mazandaran University of Medical Sciences, 2022
Background and purpose: Occlusal plane in edentulous patients is lost and needs to be reconstructed. The most common method for reconstructing occlusal plane is to make it parallel to the ala-tragus line.
Negareh Salehabadi, Navid Pournasiri, Tahmineh Bamdadian, Kosar Dadgar, Hadi Mokhtarpour, Alireza Khalilian, Mohammad Ebrahimi Saravi   +6 more
doaj  

Common Best Proximity Points in CR Metric Spaces

Iraqi Journal of Science
Throughout this paper, a new generalization of complex valued CR  -metric space is used. This definition was stated in published research as a previous work. In this paper, some new results on common best proximity points for non-self-mappings are obtained in these spaces. It is an extension of previous results proven in classical complex metric spaces.
Annam Nama Faraj, Salwa Salman Abed
openaire   +1 more source

Best Proximity Point Results in G-Metric Spaces [PDF]

, 2014
G-metric spaces proved to be a rich source for fixed point theory; however, the best proximity point problem has not been considered in such spaces. The aim of this paper is to introduce certain new classes of proximal contraction mappings and establish ...
P. Salimi, N. Hussain, A. Latif
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

A Study of Damage Patterns on Passenger Cars Involved in Road Traffic Accidents

Journal of Robotics, 2019
Health emergencies occur in passenger cars where victims do not have immediate access to either layperson or professional, proper medical services, resulting in deterioration of their health or death.
Joseph Kurebwa, Tawanda Mushiri
doaj   +1 more source