Results 61 to 70 of about 12,111,967 (266)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Study of Damage Patterns on Passenger Cars Involved in Road Traffic Accidents

Journal of Robotics, 2019
Health emergencies occur in passenger cars where victims do not have immediate access to either layperson or professional, proper medical services, resulting in deterioration of their health or death.
Joseph Kurebwa, Tawanda Mushiri
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Common best proximity point theorems under proximal F ρ ♭ $F_{\rho \flat}$ -weak dominance with application

Fixed Point Theory and Algorithms for Sciences and Engineering
In partial ♭-metric spaces, we first define F ρ ♭ $F_{\rho \flat}$ -weak contraction mappings and develop fixed point theorems in these mappings.
Asaye Ayele, Kidane Koyas
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

φ-Best proximity point theorems and applications to variational inequality problems

, 2017
The main concern of this study is to introduce the notion of φ-best proximity points and establish the existence and uniqueness of φ-best proximity point for non-self mappings satisfying (F,φ)-proximal and (F,φ)-weak proximal contraction conditions in ...
Isik, Huseyin, Vetro, C., Işık, H., Hüseyin Işık, Calogero Vetro, Isik, Huseyn, Vetro, Calogero, Sezen, M. Sangurlu, M. Sangurlu Sezen, Sezen, M.S.   +9 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Best Proximity Point Results for Gamma Class of Mappings

, 2022
In this manuscript, we define the class of Γ consist of p-cyclic mapping with certain assumptions. We investigate the existence and uniqueness of a best proximity point in the setting of a metric space with an additional condition p-completeness ...
Sakthi, Ramalingam, Gülyaz Özyurt, Selma and Karpagam, Saravanan
core   +2 more sources