Results 81 to 90 of about 4,973,845 (291)

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

One Case of Common Bile Duct Cancer Mimicking Cystic Neoplasm of the Pancreas, Arising 9 Years after Excision of a Choledochal Cyst

Clinical Endoscopy, 2012
A 42-years-old woman had undergone operation for cholecochal cyst with gallbladder cancer 9 years ago. Pathology revealed a polypoid mass in the gallbladder with liver infiltration as poorly differentiated adenocarcinoma. Computed tomography, magnetic resonance cholangiopancreatography, and endoscopic ultrasound showed a newly developed suspected solid
Park, Sang Wook, Lee, Sang Hyub, Eum, Young Ook, Oh, Hong Sang, Lee, Donghyeon, Jin, Eunhyo, Chung, Kwanghyun, Hwang, Jin-Hyeok   +7 more
openaire   +2 more sources

Cystic Lesions of the Pancreas [PDF]

, 2014
With the increasing use of abdominal imaging, cystic lesions of the pancreas are being more frequently detected. These lesions may carry a significant premalignant potential.
Azzopardi, Neville
core  

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

Total duodeno-pancreatectomy for intraductal papillary and mucinous tumor of the pancreas: report of a complex case.

Batna Journal of Medical Sciences
Intraductal papillary mucinous neoplasms of the pancreas (IPMNs) are rare cystic neoplasms with significant malignant potential. Treatment is primarily based on surgical resection, tailored to the patient’s radiological and clinical profile.
Youcef KHENCHOUL, Hichem El Azhari BENMAMAR, Mustapha BOUMENDJEL, Dalel ZERROUK, Imen HAMIOUDA   +4 more
doaj   +1 more source

OUTCOMES OF PATIENTS UNDERGOING PANCREATODUODENECTOMY (WHIPPLE’S PROCEDURE) ACCORDING TO THE PRESENCE OF PREOPERATIVE BILIARY DRAINAGE [PDF]

Arquivos de Gastroenterologia
Background: Pancreaticoduodenectomy is the procedure of choice for the treatment of resectable pancreaticoduodenal tumours. It has been proposed that jaundice is associated with worse outcomes, but the usefulness of preoperative biliary drainage in these
Rómulo VARGAS-RUBIO, Ana Maria LEGUIZAMO-NARANJO, Oscar MUÑOZ-VELANDIA, Cristiam David PULGARIN-HERRERA, Carlos Ernesto LOMBO, Liliana CUEVAS-LOPEZ, Elio Fabio SANCHEZ, Francisco Javier HENAO   +7 more
doaj   +1 more source

Giant common bile duct stone

, 2011
Bile duct stones, which obstruct the common bile duct, potentially result in complications, such as acute cholangitis and pancreatitis. We present a case involving a patient with normal liver function tests from whom we removed a giant common bile duct ...
Hyung Han, Song Tae, Lee Jin, Han Hyung, Jin Lee, Tae Song   +5 more
core   +1 more source

Intraductal papillary growth of liver metastasis originating from colon carcinoma in the bile duct: report of a case. [PDF]

, 2011
Morphologically, liver metastases from colorectal carcinoma usually form as nodular tumor masses, whereas intraductal papillary growth in the bile duct is rare.
Hiroaki Takeshita, Nanashima, Atsushi, Araki, Masato, Abe, Kuniko, Masato Araki, Atsushi Nanashima, Tohru Nakagoe, Harada, Kenichi, Kunizaki, Masaki, Takeshita, Hiroaki, Sawai, Terumitsu, Kuniko Abe, Nagayasu, Takeshi, Syuuichi Tobinaga, Hideyuki Hayashi, Terumitsu Sawai, Masaki Kunizaki, Yasuni Nakanuma, Hayashi, Hideyuki, Takeshi Nagayasu, Nakagoe, Tohru, Kenichi Harada, Tobinaga, Syuuichi, Nakanuma, Yasuni   +23 more
core   +1 more source

Bio‐Memristor Based on Clinical Bile Samples: A Proof‐of‐Concept Pilot Study for Detection of Gallbladder Cancer

Advanced Science, EarlyView.
In this work, we present a bile‐based memristor hardware framework that enables direct, label‐free identification of cholelithiasis and gallbladder cancer at the device level. The Ag/bile/FTO memristor features stable resistive switching and disease‐specific electrical responses, providing a conceptual foundation for circuits and an integrated ERCP ...
Junming Zhu, Yiyin Rong, Bai Sun, Ziwen Sun, Yifan Wang, Xiaobin Ren, Zelin Cao, Kaikai Gao, Jiawei Yu, Zhenkun Wang, Haoxuan Ma, Jichun Guo, Kai Cao, Mengrun Kang, Songling Wang, Fenggang Ren, Yi Lv, Qiang Lu   +17 more
wiley   +1 more source

Tratamento laparoscópico de coledocolitíase Laparoscopic treatment of common bile duct lithiasis

Arquivos de Gastroenterologia, 2000
Paciente com história de 18 meses de emagrecimento e icterícia foi encaminhado ao Serviço de Cirurgia Abdominal do Hospital do Câncer, São Paulo, SP., com hipótese diagnóstica de câncer de cabeça de pâncreas.
Marcel Autran C. MACHADO, Julio Rafael Mariano da ROCHA, Paulo HERMAN, André Luís MONTAGNINI, Marcel Cerqueira Cesar MACHADO   +4 more
doaj   +1 more source