Results 81 to 90 of about 3,542,049 (321)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
(C , Ψ * , G ) Class of Contractions and Fixed Points in a Metric Space Endowed with a Graph
Mathematics, 2019 In this paper, we introduce the ( C , Ψ * , G ) class of contraction mappings using C-class functions and some improved control functions for a pair of set valued mappings as well as a pair of single-valued mappings, and prove common fixed ...
Reny George +4 more
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
A simple computational algorithm with inertial extrapolation for generalized split common fixed point problems. [PDF]
Heliyon, 2021 Gebrie AG, Bedane DS.
europepmc +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The Existence of Cone Critical Point and Common Fixed Point with Applications
Journal of Applied Mathematics, 2011 We first establish some new critical point theorems for nonlinear dynamical systems in cone metric spaces or usual metric spaces, and then we present some applications to generalizations of Dancš-Hegedüs-Medvegyev's principle and the existence theorem ...
Wei-Shih Du
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Common Fixed Point Theorems for Four Fuzzy Mappings
International Journal of Analysis and Applications, 2014 In this paper, we obtain some common fixed point theorems for four fuzzy mappings in complete ordered metric linear spaces. These mappings are assumed to satisfy certain contractive inequality involving functions which are generalizations of altering ...
Animesh Gupta, Neelesh Pandey
doaj +2 more sources