Results 151 to 160 of about 162,674 (286)

Alternative Developmental Toxicity Screening Methods Using Chick Embryo‐Based Models

Journal of Applied Toxicology, EarlyView.
ABSTRACT Nonclinical developmental toxicity studies are used to investigate the potential toxicities of drugs and chemical candidates on normal embryonic and fetal development during pregnancy, generally using mammalian laboratory animals such as rats and rabbits.
Jeong Hwan Kim, Cheoljin Park, Donghee Kim, Wonjun Jeong, Jinsoo Lee   +4 more
wiley   +1 more source

Molecular dynamics simulations of oleuropein diffusion in chitosan‐based nanoparticles

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND This study explores the diffusion mechanisms of oleuropein (OLE), a promising polyphenolic compound, within chitosan‐based nanoparticles using molecular dynamics simulations. Chitosan nanoparticles serve as drug delivery carriers, leveraging biocompatibility and tunable release properties influenced by environmental factors such as ...
Bernardino Tirri, Andrea Lorenzoni, Francesco Mercuri, Pietro Calandra   +3 more
wiley   +1 more source

Do common frogs (Rana temporaria) follow Bergmann's rule?

, 2005
Questions: Does intraspecific extension of Bergmann's rule - larger size within a species in cooler areas - hold true for ectotherms in general, and for the common frog (Rana temporaria) in particular? What is the relative importance of genetic and environmental factors (i.e.
Laugen, A T, Laurila, A, Jönsson, Ingemar, Söderman, F, Merilä, J   +4 more
openaire   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Emergence of cellular nematic order is a conserved feature of gastrulation in animal embryos

Nature Communications
Cells undergo dramatic morphological changes during embryogenesis, yet how these changes affect the formation of ordered tissues remains elusive. Here, we show that a phase transition leading to the formation of a nematic liquid crystal state during ...
Xin Li, Robert J. Huebner, Margot L. K. Williams, Jessica Sawyer, Mark Peifer, John B. Wallingford, D. Thirumalai   +6 more
doaj   +1 more source

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Genome size variation in the common frog Rana temporaria.

Hereditas, 2007
Genome size variation in the common frog (Rana temporaria) was investigated with flow cytometry in three latitudinally separated populations in Sweden to see whether it could provide a useful tool for sex-identification in this species. Depending on the sex and population, per cell DNA content (2C value) varied from 8.823 to 11.266 pg with a mean ...
Chikako, Matsuba, Juha, Merilä
openaire   +1 more source

Frontiers of Bright CEP‐Stable Broadband Infrared Sources

Laser &Photonics Reviews, EarlyView.
Bright CEP‐stable broadband infrared sources push the limits of ultrafast science by delivering exceptional brightness alongside few‐cycle durations and multi‐octave spectral coverage. This review highlights emerging architectures and nonlinear conversion strategies that scale power while preserving phase stability.
Ugaitz Elu, Jens Biegert
wiley   +1 more source

In Situ Acoustic Monitoring of Focused Femtosecond Pulse Duration in Air

Laser &Photonics Reviews, EarlyView.
Air‐breakdown acoustics at the laser focus is used to determine femtosecond pulse duration with a simple USB microphone. By chirp‐tuning and compressing 1030 nm pulses from 241 to 50 fs, the acoustic amplitude scales inversely proportional to the square root of the pulse duration, enabling in situ readout over 50 fs–5 ps—crucial for precise pulse ...
Indrė Meškėlaitė, Hsin‐Hui Huang, Haoran Mu, Nguyen Hoai An Le, Tomas Katkus, Edvinas Aleksandravičius, Gabrielius Kontenis, Domas Paipulas, Saulius Juodkazis, Darius Gailevičius   +9 more
wiley   +1 more source

Continuous Apomorphine Infusion in Multiple System Atrophy Real‐World Insights From a French Nationwide Retrospective Cohort

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Continuous subcutaneous apomorphine infusion (CSAI) is effective in Parkinson's disease but has not been evaluated in multiple system atrophy (MSA). Objective To assess the 6‐month efficacy and tolerability of CSAI in MSA patients. Methods French multicenter retrospective registry‐based analysis of CSAI use in MSA.
Simon Lamy, Frederique Leh, Alexandra Foubert‐Samier, Soizic Leguy Bonnet, Guillaume Baille, Margherita Fabbri, Margaux Dunoyer, Lise Mantisi, Caroline Giordana, Anaïs El Ouartassi, Olivier Rascol, Wassilios G. Meissner, David Bendetowicz, Marie Vanel, David Grabli, Fabienne Ory‐Magne, Sophie Drapier   +16 more
wiley   +1 more source