Results 151 to 160 of about 99,860 (311)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
A Preference-Theoretic Methodology for Nonmarket Goods [PDF]
A methodology for nonmarket goods is presented based on preference algebra and set theory that allows us to specify exactly when preference assumptions such as weak complementarity can be tested against revealed preference information.
David G. Brown
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
What role for public goods in the future of CAP?
The European Union’s Common Agricultural Policy continues to evolve. The public debate about its future post 2013 was launched in April 2010 and a formal Commission Communication on the future of the Common Agriculture Policy (CAP) was published in ...
Harvey, David R., Jambor, Attila
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Communication, Advice and Beliefs in an Experimental Public Goods Game [PDF]
We study the efficacy of horizontal versus vertical social learning processes in a public goods game. In one treatment, subjects about to play the game can make nonbinding common knowledge announcements about their intentions while, in another, subjects ...
Susan Skeath +2 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Should the Government Finance Public Goods in Rural Areas? A Review of Arguments [PDF]
This paper reviews three arguments why government should not directly finance public goods provision in the countryside: (1) sorting and voting of residents leads to efficient local public goods provision, (2) community governance better copes with ...
Petrick, Martin
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Financing Common Goods for Health: Sri Lanka
Health Systems & Reform, 2019 Palitha Abeykoon
doaj +1 more source
Planning For Unmet Social Needs In Pandemics: Teachers' Experiences Of Unacknowledged Care Work. [PDF]
Public Health EthicsWilliams J +5 more
europepmc +1 more source