Results 91 to 100 of about 141,769 (294)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Modeling and analysis of common-mode voltages generated in medium voltage PWM-CSI drives

IEEE Transactions on Power Electronics, 2003
Common-mode voltages appear in pulse-width modulated current-source inverters (PWM-CSIs) drives due to the operating principles of the input rectifier and the output inverter. This paper presents the modeling and analysis of a medium voltage current-source inverter drive, using the Matlab software.
Rodriguez, J, Moran, L, Pontt, J, Osorio, R, Kouro, S   +4 more
openaire   +3 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Three-level inverter fed open-end winding IM drive with common mode voltage elimination and reduced power device count

, 2007
A three-level space phasor generation scheme with common mode elimination and with reduced power device count is proposed for an open end winding induction motor in this paper. The open end winding induction motor is fed by the three-level inverters
Sivakumar, K, Figarado, Sheron, Mondal, Gopal, Gopakumar, K, Dinesh, NS   +4 more
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

A Study on Various Causes of Low Frequency Components in Common Mode Voltage of a Space Vector Pulse Width Modulated Three– Phase Quasi–Z–Source H–Bridge Inverter Fed from a Three–Phase Diode Bridge Rectifier

Power Electronics and Drives
The presence of low frequency components in the common mode voltage can cause harmful electromagnetic interference. A critical study on various causes of low frequency components in the common mode voltage of a space vector pulse width modulated Quasi–Z–
Nanda Debalina, Syam Prasid, Mukherjee Kaushik   +2 more
doaj   +1 more source

Space-Vector PWM With Common-Mode Voltage Elimination for Multiphase Drives

IEEE Transactions on Power Electronics, 2016
Switching common-mode voltage (CMV) generated by the pulse width modulation (PWM) of the inverter causes common-mode currents, which lead to motor bearing failures and electromagnetic interference problems in multiphase drives. Such switching CMV can be reduced by taking advantage of the switching states of multilevel multiphase inverters that produce ...
Oscar Lopez, Jacobo Alvarez, Jano Malvar, Alejandro G. Yepes, Ana Vidal, Fernando Baneira, Diego Perez-Estevez, Francisco D. Freijedo, Jesus Doval-Gandoy   +8 more
openaire   +3 more sources

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source