Results 101 to 110 of about 141,769 (294)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Reduction of the common mode voltage of a matrix converter fed direct torque control [PDF]

open access: yes, 2010
The work presented in this paper proposes an approach to reduce the common mode voltage at the output of matrix converters when a direct torque control scheme is employed to drive a permanent magnet synchronous motor.
Carlos Ortega   +7 more
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

open access: yesFEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia   +6 more
wiley   +1 more source

Performance characteristics of the reduced common mode voltage near state PWM method

open access: yes, 2007
The Near State PWM (NSPWM) method, which has low common mode voltage/current is proposed for three-phase voltage source inverter drives. The method is described and its voltage linearity, output current ripple, DC bus current ripple, common mode voltage ...
Un, Emre   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Comparison of Multilevel Inverters for the Reduction of Common Mode Voltage

open access: yes, 2013
This paper presents a comparison between NPC (neutral point clamped) and H-cascaded multilevel inverters by considering the increas or decrease of harmonics in the output line to line voltages,  phase voltages and common mode voltage.
Jamil, Muhammad
core   +1 more source

Research on Mechanism and Suppression Technique of Metro Vehicles Traction Motor Bearing Electrocorrosion

open access: yes机车电传动, 2019
In order to solve the problem of electrocorrosion of traction motor bearings of metro vehicles, the fault mechanism was analyzed, and the solutions were put forward and verified.
Guanglin YAN   +3 more
doaj  

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