Results 41 to 50 of about 162,460 (297)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The distributional impact of common‐pool resource regulations [PDF]
Indian Growth and Development Review, 2011 PurposeRegulating common‐pool resources is welfare enhancing for society but not necessarily for all users who may therefore oppose regulations. The purpose of this paper is to examine the short‐term impact of common‐pool resource regulations on welfare distribution.Design/methodology/approachThe authors model a game of common‐pool resource extraction ...
Ambec, Stefan, Sebi, Carine
openaire +4 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
One size fits all? Designer-institutions: Lessons from two flawed attempts in Malawi
International Journal of the Commons, 2010 This article observes two examples of attempted institutional design in Malawi's central region, Kasungu. In both cases external development actors enter local communities, and establish infrastructure to exploit two common sources of water.
Tomas Moe Skjølsvold
doaj +1 more source
Ecology and Society, 2022 The state of Nebraska, USA employs a localized, integrated approach to managing water resources to address escalating quantity challenges. Here, we assess differences between agricultural water users’ perceptions of water management in a water-stressed ...
Mark E Burbach +4 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
International Journal of the Commons, 2015 Our study focuses on pasture reform in Azerbaijan within the context of transition and pasture reform in Central Asian and Caucasian countries. Despite the rapid emergence of individualised rights for pasture plots, which is an exceptional development in
Regina Neudert +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
International Journal of the Commons, 2011 This paper analyses the international regime governing the use of broadcasting frequencies in the long and medium wave bands in Europe from 1950 until 1970.
Christian Henrich-Franke
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Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source