Results 41 to 50 of about 958,486 (307)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
One size fits all? Designer-institutions: Lessons from two flawed attempts in Malawi
International Journal of the Commons, 2010 This article observes two examples of attempted institutional design in Malawi's central region, Kasungu. In both cases external development actors enter local communities, and establish infrastructure to exploit two common sources of water.
Tomas Moe Skjølsvold
doaj +1 more source
Ecology and Society, 2022 The state of Nebraska, USA employs a localized, integrated approach to managing water resources to address escalating quantity challenges. Here, we assess differences between agricultural water users’ perceptions of water management in a water-stressed ...
Mark E Burbach +4 more
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
International Journal of the Commons, 2015 Our study focuses on pasture reform in Azerbaijan within the context of transition and pasture reform in Central Asian and Caucasian countries. Despite the rapid emergence of individualised rights for pasture plots, which is an exceptional development in
Regina Neudert +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
International Journal of the Commons, 2011 This paper analyses the international regime governing the use of broadcasting frequencies in the long and medium wave bands in Europe from 1950 until 1970.
Christian Henrich-Franke
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Poverty and the Environment: Exploring the Relationship between Household Incomes, Private Assets, and Natural Assets [PDF]
Using purpose-collected survey data from 537 households in 60 different villages of the Jhabua district of India, this paper investigates the extent to which rural households depend on common-pool natural resources for their daily livelihood.
Gupta, Shreekant +2 more
core +3 more sources
The role of institutions in community wildlife conservation in Zimbabwe
International Journal of the Commons, 2018 Institutions play a significant role in stabilizing large-scale cooperation in common pool resource management. Without restrictions to govern human behaviour, most natural resources are vulnerable to overexploitation.
Herbert Ntuli, Edwin Muchapondwa
doaj +1 more source