Results 81 to 90 of about 9,029,502 (230)

Haematological Emergencies

Proceedings of Singapore Healthcare, 2014
In a hospital setting, it is common to encounter certain haematological emergencies irrespective of whether or not the patient has an underlying haematological condition or if the hospital has a well-established haematology service.
Hui Ming Tay MBBS, MRCP, MMed (Int Med)
doaj   +1 more source

Iron supplementation in Switzerland – a bi-national, descriptive, observational study

Swiss Medical Weekly, 2017
BACKGROUND Iron deficiency is the most common nutritional disorder in the world, and it is the only common nutrient deficiency in industrialised nations. It is thought to be the most common cause of anaemia.
Fabienne A. Biétry, Balthasar Hug, Oliver Reich, Susan S Jick, Christoph R. Meier   +4 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Pirtobrutinib monotherapy in Bruton tyrosine kinase inhibitor-intolerant patients with B-cell malignancies: results of the phase I/II BRUIN trial

Haematologica
Bruton tyrosine kinase inhibitors (BTKi) have transformed the treatment of B-cell malignancies, but intolerance has often led to their discontinuation. The phase 1/2 BRUIN study evaluated pirtobrutinib, a highly selective non-covalent (reversible) BTKi,
Nirav N. Shah, Michael Wang, Lindsey E. Roeker, Krish Patel, Jennifer A. Woyach, William G. Wierda, Chaitra S. Ujjani, Toby A. Eyre, Pier Luigi Z inzani, Alvaro J. Alencar, Paolo Ghia, Nicole Lamanna, Marc S. Hoffmann, Manish R. Patel, Ian Flinn, James N. Gerson, Shuo Ma, Catherine C. Coombs, Chan Y. Cheah, Ewa Lech-Maranda, Bita Fakhri, Won Seog Kim, Minal A. Barve, Jonathon B. Cohen, Wojciech Jurczak, Talha Munir, Meghan C. Thompson, Donald E. Tsai, Katherine Bao, Nicholas A. Cangemi, Jennifer F. Kherani, Richard A. Walgren, Hongmei Han, Amy S. Ruppert, Jennifer R. Brown   +34 more
doaj   +1 more source

Impact of nonlinearity on changing the a priori of trace gas profile estimates from the Tropospheric Emission Spectrometer (TES) [PDF]

Atmospheric Chemistry and Physics, 2008
Non-linear maximum a posteriori (MAP) estimates of atmospheric profiles from the Tropospheric Emission Spectrometer (TES) contains a priori information that may vary geographically, which is a confounding factor in the analysis and physical ...
S. S. Kulawik, K. W. Bowman, M. Luo, C. D. Rodgers, L. Jourdain   +4 more
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Emergency department visits and dental procedures: Mission of Mercy, 2013–2016

Clinical, Cosmetic and Investigational Dentistry, 2019
Christopher Okunseri,1 Stephanie Zbin,1 Cheng Zheng,2 Frederick Eichmiller,3 Elaye Okunseri,1 Aniko Szabo41School of Dentistry, Department of Clinical Services, Marquette University, Milwaukee, WI, USA; 2Joseph. J.
Okunseri C, Zbin S, Zheng C, Eichmiller F, Okunseri E, Szabo A   +5 more
doaj  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Characteristics of participants in the national research mentoring network studies

Journal of Clinical and Translational Science
Introduction: This paper presents a descriptive analysis of common data collected across 11 independent studies in the National Research Mentoring Network (NRMN) from 2019 to 2024, focusing on participant demographics and participation in training ...
So Hee Hyun, Emma Dums, Fátima Sancheznieto, Kimberly Spencer, Julie M. Hau, Jenna Griebel Rogers, Christine Pfund   +6 more
doaj   +1 more source