Results 41 to 50 of about 313,173 (266)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A Bayesian Hierarchical Approach to Quasi-Replicate Dataset Modelling
MathematicsIt is very common for multiple experiments to be conducted under non-identical but similar conditions, perhaps because of implementation errors, natural variability in experimental material, or gradual drifting of experimental conditions. In the extremes
Hassan M. Aljohani, Robert G. Aykroyd
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Struggling to Make Good: The Dilemmas of Fatherhood for Formerly Incarcerated African American Men
, 2021 While some have argued that absent low socioeconomic status black fathers are to blame for urban crime and poverty, others have highlighted how mass incarceration disproportionately separates low socioeconomic status black fathers from their children ...
Prior, Francis B., Farough, Steven
core +1 more source
BuildingsThe use of drywall as a non-structural infill has grown significantly due to its rapid and economical installation. Despite this widespread use, a common assumption in structural design is that these elements do not significantly affect seismic ...
Jorge I. Garcés +3 more
doaj +1 more source
Phylogenetic detection of recombination with a Bayesian prior on the distance between trees. [PDF]
PLoS ONE, 2008 Genomic regions participating in recombination events may support distinct topologies, and phylogenetic analyses should incorporate this heterogeneity.
Leonardo de Oliveira Martins +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Speculative Trade under Unawareness: The Infinite Case [PDF]
We generalize the ``No-speculative-trade" theorem for finite unawareness belief structures in Heifetz, Meier, and Schipper (2013) to the infinite case.Awareness, unawareness, speculation, trade, agreement, common prior, common ...
Martin Meier, Burkhard C. Schipper
core +2 more sources
Museums and a common world: climate change, cosmopolitics, museum practice
Museum & Society, 2011 At stake in this paper is the nature of the relationship between the institution of the museum and the common world. It is contended that such relations are regularly asserted through cosmopolitan appeals, which are premised on the assumption that a ...
Ben Dibley
doaj