Results 91 to 100 of about 3,872 (299)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Scaling-up territorial alternatives to water extractivism: mini hydroelectric plants in Ecuador
, 2020 by Emilie Dupuits The second post of the series “Reimagining, remembering, and reclaiming water: from extractivism to commoning” co-organized by the Undisciplined Environments and FLOWs blogs, discusses controversies and challenges in scaling up social
water commoning
core
Revaluing the foundation(al): the role of commons for social-ecological provisioning
Sustainability: Science, Practice, & PolicyThe capitalist growth paradigm’s continuous production of intertwined and mutually reinforcing crises underscores the need for a social-ecological transformation toward a more just and sustainable economy.
Anine Hvid Nikolajsen, Corinna Dengler
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Commons Praxis: Toward a Critical Political Economy of the Digital Commons
tripleC: Communication, Capitalism & Critique, 2018 The concept of the commons has provided a useful framework for understanding a wide range of resources and cultural activities associated with the creation of value outside of the traditional market mechanisms under capitalism (i.e., private property ...
Benjamin J Birkinbine
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
BMJ, 2004 Do patients with venous ulcers get pain A: most of the time? B: commonly? C: often? D: rarely? We all use imprecise terms in our writing, but such terms cause confusion when they are used in examination questions. We have all experienced sitting an examination and wondering what …
openaire +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Appreciative commoning; Musical knowledge-sharing in Earhouse Songwriting Club
Wacana: Journal of the Humanities of IndonesiaThis article develops the concept of “appreciative commoning” to focus on the importance of appreciation in musical community practices. By examining the practices of musical knowledge-sharing in the Earhouse Songwriting Club (ESC), a songwriting ...
Arya J. P. Adyuta
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source