Results 101 to 110 of about 2,427 (307)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Commoning (in) the neighbourhood, righting the city [PDF]

open access: yes, 2023
The advent of the urban commons as a response to the commodification of urban life (Foster & Iaione, 2016) and its excluding impact on the urban populations has consolidated a network of social actions, namely acts of commoning (Linebaugh, 2008) that ...
Paio, A., Pappa, A.
core  

How common is common? [PDF]

open access: yesBMJ, 2004
Do patients with venous ulcers get pain A: most of the time? B: commonly? C: often? D: rarely? We all use imprecise terms in our writing, but such terms cause confusion when they are used in examination questions. We have all experienced sitting an examination and wondering what …
openaire   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Catalytic commoning [PDF]

open access: yes, 2015
This exhibition explores relationships between film, architecture and the city. The installations weave together film, scenographics, architectural interventions and issues of public space. Investigating the processes of design and the teaching of design,
Paul, Lewis, Taylor, Sarah
core  

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

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