Results 101 to 110 of about 3,872 (299)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Heterodox modeling: practicing well-tuned provisioning or commoning with networked multi-agent environments. [PDF]
Rev Evol Polit Econ, 2023 Miyazaki S.
europepmc +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Commoning genomic solidarity to improve global health equality. [PDF]
Cell Genom, 2023 Zhang JY.
europepmc +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Commoning the governance: a review of literature and the integration of power. [PDF]
Sustain Sci, 2023 Partelow S, Manlosa AO.
europepmc +1 more source
Collective Subjectivation in Socially Innovative Commoning
International Journal of the CommonsThis paper focuses on subjectivities of agents involved in socially innovative commoning practices. Social change agents, often influenced by neoliberal ideologies and individualist subjectivities, sometimes prioritize ‘practical’ approaches over ...
Frank Moulaert +2 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Welcome to Commoning Ethnography [PDF]
, 2018 What does it mean to suggest that ethnography might be a site, source, or scene of commoning? What does combining the idea of commoning with the practice of ethnography allow us to think about or to do that we might not otherwise?
Elinoff, Eli, Trundle, Catherine
core +1 more source