Results 111 to 120 of about 3,872 (299)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Micro-Care in Motion: Commoning Kindness as Ethical Planning Practice

open access: yes
This presentation explores how everyday mobility depends not only on transport infrastructure, but also on small acts of care, kindness, and support that help people move, wait, and navigate vulnerability.
Wendy Tan, Enrica Papa
core   +1 more source

Riverhood: political ecologies of socionature commoning and translocal struggles for water justice. [PDF]

open access: yesJ Peasant Stud, 2023
Boelens R   +28 more
europepmc   +1 more source

A commoning framework for environmental archaeology: beyond resource management in Indigenous North America

open access: yesFrontiers in Environmental Archaeology
Environmental archaeology has often relied on common-pool resource models to interpret past human-environment relationships, yet these frameworks overlook Indigenous ontologies grounded in kinship with land, water, and more-than human beings.
Jessica A. Jenkins   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Rethinking GLAMs as commons: a conceptual framework. [PDF]

open access: yesOpen Res Eur, 2023
Avdikos V   +3 more
europepmc   +1 more source

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