Results 141 to 150 of about 6,508,204 (342)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Parliament bounces back – how Select Committees have become a power in the land [PDF]
, 2013 Much reformist discussion of the House of Commons views it as an institution in permanent decline, operating in a museum-building with stuffy and out-of-date processes that MPs stubbornly refuse to change.
Dunleavy, Patrick, Muir, Dominic
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Communications Earth & EnvironmentScaling up CO2 removal is crucial to achieve net-zero targets and limit global warming. To engage with publics and ensure a social licence to deploy large-scale carbon dioxide removal (CDR), better understanding of public perceptions of these ...
Tim Repke +3 more
doaj +1 more source
Book review: parliamentary socialisation: learning the ropes or determining behaviour? by Michael Rush and Philip Giddings [PDF]
, 2012 How and from whom do MPs learn about their role in the Commons? In Parliamentary Socialisation, Michael Rush and Philip Giddings consider the range of sources that provide socialisation for MPs as they enter the House of Commons.
O'Brien, Dave
core
"Afterword: After the commons -commoning"
Focaal, 2017 Commoning over time generates customs in common and therefore commonalities. The political mobilizations of the past years may well be understood as a form of urban commoning. However, while such mobilizations may sometimes understand themselves as anticapitalist, one should resist the apparently logical idea (1) that the use values off ered by an ...
openaire +3 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Revisiting the commons: local lessons, global challenges.
Science, 1999 E. Ostrom +4 more
semanticscholar +1 more source