Results 91 to 100 of about 2,578,068 (346)

Primary Health Care: a strategic framework for the prevention and control of chronic non-communicable disease

Global Health Action, 2014
In 2014, chronic, non-communicable diseases (NCDs) represent the leading causes of global mortality and disability. Government-level concern, and resulting policy changes, are manifesting.
A. Demaio, Karoline Kragelund Nielsen, B. Tersbøl, P. Kallestrup, D. Meyrowitsch   +4 more
semanticscholar   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Impact of two-dose varicella vaccination in Guangzhou: An interrupted time-series study

Human Vaccines & Immunotherapeutics
In November 2017, Guangzhou implemented a self-paid two-dose varicella vaccination program. This study evaluated the program’s impact on varicella incidence trends across the general population and specific age groups. An interrupted time-series analysis
Huan Zhang, Yanhui Liu, Xing Ye, Lei Luo, Qing He   +4 more
doaj   +1 more source

A comparison of DALYs for periodontal disease in China between 1990 and 2013: insights from the 2013 global burden of disease study

BMC Oral Health, 2017
Background China has undergone a rapid demographic and epidemiological transition with fast ecomonic development since the 1980s. Oral health is becoming a major public health problem as the prevalence of non-communicable diseases has greatly increased ...
Qi Zhang, Zhixin Li, Chunxiao Wang, Yunning Liu, Yang Yang, Scottie Bussell, Maigeng Zhou, Linhong Wang   +7 more
doaj   +1 more source

Witnessing history: a personal view of half a century in public health [PDF]

, 2018
Former Chief Medical Officer Sir Kenneth Calman recently celebrated 50 years in medicine. It was a period which saw the evolution of the public health agenda from communicable diseases to diseases of lifestyle, the change from a hospital-orientated ...
Bergman, B.P., Calman, K.C., Chandler, A.S., Laing, F.   +3 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Newly estimated disability weights for 196 health states in Hubei Province, China

Population Health Metrics
Background The disability weight (DW) reflects the severity of non-fatal outcomes and is an important parameter in calculating the burden of disease. However, the universality of the global, national, or subnational DWs remains controversial.
Mengge Zhou, Lan Zhang, Tianjing He, Shuzhen Zhu, Yumeng Tang, Qian Li, Miaoyan Shen, Jingju Pan   +7 more
doaj   +1 more source

Communicable Disease Control [PDF]

AJN, American Journal of Nursing, 1948
Gaylord W. Anderson, Margaret G. Amstein
  +6 more sources

Hypertension testing and treatment in Uganda and Kenya through the SEARCH study: An implementation fidelity and outcome evaluation. [PDF]

, 2020
BackgroundHypertension (HTN) is the single leading risk factor for human mortality worldwide, and more prevalent in sub-Saharan Africa than any other region [1]-although resources for HTN screening, treatment, and control are few.
Ayieko, James, Balzer, Laura B, Byonanabye, Dathan M, Chamie, Gabriel, Charlebois, Edwin D, Clark, Tamara D, Cohen, Craig R, Havlir, Diane, Heller, David J, Jain, Vivek, Kahn, James G, Kamya, Moses R, Kazi, Dhruv, Kotwani, Prashant, Kwarisiima, Dalsone, Mwangwa, Florence, Petersen, Maya   +16 more
core   +1 more source