Results 71 to 80 of about 2,470,242 (348)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Newly estimated disability weights for 196 health states in Hubei Province, China

Population Health Metrics
Background The disability weight (DW) reflects the severity of non-fatal outcomes and is an important parameter in calculating the burden of disease. However, the universality of the global, national, or subnational DWs remains controversial.
Mengge Zhou, Lan Zhang, Tianjing He, Shuzhen Zhu, Yumeng Tang, Qian Li, Miaoyan Shen, Jingju Pan   +7 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Clinical characteristics and risk factors of Hepatitis E virus infection in Zhejiang Province: a multicenter case–control study

Frontiers in Public Health
IntroductionHepatitis E (HE), caused by the Hepatitis E virus (HEV), is a significant cause of acute viral hepatitis globally and a major public health concern, particularly in specific high-prevalence areas in China, which have diverse transmission ...
Yijuan Chen, Jian Gao, Wanwan Sun, Weiping Zhu, Pingping Wang, Xiaobin Ren, Yumeng Wu, Jianli Zhang, Ziping Miao   +8 more
doaj   +1 more source

Communicable Disease Center activities, 1947-1948 [PDF]

This report is intended to summarize the major activities of the Communicable Disease Center during the fiscal year 1948. The text is arranged in a manner thought applicable to the focusing of attention upon the basic objectives and accomplishments of ...

core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Comparison of novel and traditional anthropometric indices in Eastern-China adults: which is the best indicator of the metabolically obese normal weight phenotype?

BMC Public Health
Background People with the metabolically obese normal weight (MONW) phenotype have been confirmed to significantly increase the risk of unfavorable health consequences.
Yijia Chen, Chenchen Wang, Qiannan Sun, Qing Ye, Hairong Zhou, Zhenzhen Qin, Shengxiang Qi, Weiwei Wang, Xin Hong   +8 more
doaj   +1 more source

Characteristics and timeliness of intervention in 47 school-based enterovirus outbreaks in Zhejiang Province, China

Frontiers in Public Health
BackgroundHand, foot, and mouth disease (HFMD) and herpangina (HA) are common infectious diseases in children that can frequently lead to outbreaks. Analyzing the characteristics of school-based outbreaks and evaluating the timeliness of prevention and ...
Yijuan Chen, Wanwan Sun, Xiaobin Ren, Xiaomin Gu, Kai Song, Pingping Wang, Yanli Cao, Jianmin Jiang, Jianmin Jiang, Ziping Miao, Ziping Miao   +10 more
doaj   +1 more source

Communicable Disease Center 1951-1952 activities. [PDF]

The Communicable Disease Center, a component of the Bureau of State Services of the U. S. Public Health Service, operates on a Nation-wide basis. Its primary responsibility is to assist States and Territories to develop and implement increasingly ...

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Clusters of meningococcal disease in educational establishments in the United Kingdom: April 2001 to March 2002. [PDF]

, 2004
Clusters of meningococcal disease in school and pre-school settings generate high levels of public anxiety. Thus, cluster detection and reporting is crucial to trigger prompt public health measures, and detailed study is essential to shape future public ...
Davison, K, Granerød, J, Stuart, J, Crowcroft, N, Health Protection Agency Communicable Disease Surveillance Centr   +4 more
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