Results 61 to 70 of about 2,470,242 (348)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, Volume 20, Issue 6, Page 1612-1625, June 2026.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Communicable Diseases and Outbreak Control.

Turkish journal of emergency medicine, 2016
Infectious disease during an emergency condition can raise the death rate 60 times in comparison to other causes including trauma. An epidemic, or outbreak, can occur when several aspects of the agent (pathogen), population (hosts), and the environment create an ideal situation for spread.
openaire   +2 more sources

Public health stakeholders' perceived status of health communication activities for the prevention and control of communicable diseases across the EU and EEA/EFTA countries [PDF]

, 2012
Executive summary: Health communication activities to inform and influence individual and community decisions are increasingly being used to support the prevention and control of communicable diseases.
O'Sullivan, Maeve, Mahmood, Samir, MacDonald, Laura, Oroviogoichoechea, C, Sixsmith, Jane, Barry, Margaret, Doyle, Priscilla, Guillen-Grima, Francisco, Nunez-Cordoba, Jorge, Cairns, Georgina   +9 more
core  

Addressing geographical variation in the progression of non-communicable diseases in Peru: the CRONICAS cohort study protocol. [PDF]

, 2012
Background The rise in non-communicable diseases in developing countries has gained increased attention. Given that around 80% of deaths related to non-communicable diseases occur in low- and middle-income countries, there is a need for local knowledge ...
Smeeth, Liam, Miranda, J Jaime, Bernabe-Ortiz, Antonio, CRONICAS Cohort Study Group, Checkley, William, Gilman, Robert H   +5 more
core   +1 more source

Primary Health Care: a strategic framework for the prevention and control of chronic non-communicable disease

Global Health Action, 2014
In 2014, chronic, non-communicable diseases (NCDs) represent the leading causes of global mortality and disability. Government-level concern, and resulting policy changes, are manifesting.
A. Demaio, Karoline Kragelund Nielsen, B. Tersbøl, P. Kallestrup, D. Meyrowitsch   +4 more
semanticscholar   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Impact of two-dose varicella vaccination in Guangzhou: An interrupted time-series study

Human Vaccines & Immunotherapeutics
In November 2017, Guangzhou implemented a self-paid two-dose varicella vaccination program. This study evaluated the program’s impact on varicella incidence trends across the general population and specific age groups. An interrupted time-series analysis
Huan Zhang, Yanhui Liu, Xing Ye, Lei Luo, Qing He   +4 more
doaj   +1 more source

A comparison of DALYs for periodontal disease in China between 1990 and 2013: insights from the 2013 global burden of disease study

BMC Oral Health, 2017
Background China has undergone a rapid demographic and epidemiological transition with fast ecomonic development since the 1980s. Oral health is becoming a major public health problem as the prevalence of non-communicable diseases has greatly increased ...
Qi Zhang, Zhixin Li, Chunxiao Wang, Yunning Liu, Yang Yang, Scottie Bussell, Maigeng Zhou, Linhong Wang   +7 more
doaj   +1 more source

THE CONTROL OF COMMUNICABLE DISEASES IN SCHOOLS

American Journal of Public Health, 1916
Dr. Josephine Baker, as director of one of the most important bureaus in the New York City Department of Health, has become one of the country's best known women health workers. Her experience in the matter of which this paper treats has naturally been very extensive.
openaire   +3 more sources