Results 41 to 50 of about 404,283 (311)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Uniformity in Control of Communicable Diseases

American Journal of Public Health and the Nations Health, 1942
AT the forty-third annual meeting of the American Public Health Association and the fifteenth annual conference of sanitary officers of the State of New York at Rochester, N. Y., a symposium on the administrative control of infectious diseases was held on September 10, 1915, under the joint auspices of the Section of Public Health Officials and the ...
openaire   +3 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Spicy food consumption is associated with abdominal obesity among Chinese Han population aged 30–79 years in the Sichuan Basin: a population-based cross-sectional study

BMC Public Health, 2022
Background Few animal experiments and volunteer-based intervention studies have showed a controversial effect of spicy foods on abdominal obesity. We aimed to examine the association between spicy food frequency, spicy flavor, and abdominal obesity among
Xianxian Yang, Wenge Tang, Deqiang Mao, Xiang Liu, Wen Qian, Yingxue Dai, Liling Chen, Xianbin Ding   +7 more
doaj   +1 more source

Communicable Diseases and Outbreak Control.

Turkish journal of emergency medicine, 2016
Infectious disease during an emergency condition can raise the death rate 60 times in comparison to other causes including trauma. An epidemic, or outbreak, can occur when several aspects of the agent (pathogen), population (hosts), and the environment create an ideal situation for spread.
openaire   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Public health stakeholders' perceived status of health communication activities for the prevention and control of communicable diseases across the EU and EEA/EFTA countries [PDF]

, 2012
Executive summary: Health communication activities to inform and influence individual and community decisions are increasingly being used to support the prevention and control of communicable diseases.
O'Sullivan, Maeve, Mahmood, Samir, MacDonald, Laura, Oroviogoichoechea, C, Sixsmith, Jane, Barry, Margaret, Doyle, Priscilla, Guillen-Grima, Francisco, Nunez-Cordoba, Jorge, Cairns, Georgina   +9 more
core  

Addressing geographical variation in the progression of non-communicable diseases in Peru: the CRONICAS cohort study protocol. [PDF]

, 2012
Background The rise in non-communicable diseases in developing countries has gained increased attention. Given that around 80% of deaths related to non-communicable diseases occur in low- and middle-income countries, there is a need for local knowledge ...
Smeeth, Liam, Miranda, J Jaime, Bernabe-Ortiz, Antonio, CRONICAS Cohort Study Group, Checkley, William, Gilman, Robert H   +5 more
core   +1 more source

Impact of two-dose varicella vaccination in Guangzhou: An interrupted time-series study

Human Vaccines & Immunotherapeutics
In November 2017, Guangzhou implemented a self-paid two-dose varicella vaccination program. This study evaluated the program’s impact on varicella incidence trends across the general population and specific age groups. An interrupted time-series analysis
Huan Zhang, Yanhui Liu, Xing Ye, Lei Luo, Qing He   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source