Results 41 to 50 of about 2,470,242 (348)

Cross-sectional study on prevalence and risk factors for falls among the elderly in communities of Guangdong province, China

BMJ Open, 2022
Objective This study aims to investigate the prevalence and risk factors of falls among the elderly in Guangdong, China.Methods A cross-sectional study was conducted in six communities of Guangdong province.
Chuan Li, Xue-yan Zheng, Xiao-jun Xu, Li-feng Lin, Xia-zi Lin, Rui-lin Meng, Dan-dan Peng, Hao-feng Xu   +7 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Associations of total physical activity with all-cause and cardiovascular disease mortality in Chinese adults: a prospective study

BMC Public Health
Background Evidence regarding the associations of total physical activity with all-cause and cardiovascular disease (CVD) mortality in Chinese adults is limited. The study aimed to evaluate the relationships between them.
Yanan Wan, Jinxin Yu, Hao Yu, Yu Qin, Renqiang Han, Xikang Fan, Xiaoqun Pan, Jie Yang, Quanyong Xiang, Yongqing Zhang, Ran Tao, Jinyi Zhou, Jian Su   +12 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Analysis on the prevalence and temporal trends of adverse birth outcomes among neonates in Shanghai from 2010 to 2023

Frontiers in Public Health
BackgroundPrevious research has focused on the risk factors of adverse birth outcomes and its short-term and long-term consequences. However, study on the temporal trends of adverse birth outcomes is few.
Yongfa Qin, Jia Zhao, Yiyuan Li, Jing Chen, Yin Dai, Hui Li, Tao Zhang, Zhe Sun, Ying Lu, Xue Han   +9 more
doaj   +1 more source

Evidence Review: Social Marketing for the Prevention and Control of Communicable Disease [PDF]

, 2012
Background: Social marketing is the application of marketing theories and techniques to the planning, implementation, and evaluation of programmes and interventions to influence pro-social voluntary behaviour change in order to improve personal welfare ...
MacDonald, Laura, Angus, Kathryn, Cairns, Georgina, Stead, Martine   +3 more
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source