Results 41 to 50 of about 13,770,860 (306)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Factors associated with frailty status compared to pre-frailty in community-dwelling older adults: a cross-sectional study

Frontiers in Public Health
ObjectiveTo identify factors distinguishing frail from pre-frail status in community-dwelling older adults and construct a risk prediction model with logistic regression as the primary method to identify independent risk factors, and a neural network as ...
Wei Li, Xiaodan Xue, Dandan Li, Yi Pan, Meiqiu Xie, Ying Zhang, Wenlong Zheng, Mingyue Zhang   +7 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Uniformity in Control of Communicable Diseases

American Journal of Public Health and the Nations Health, 1942
AT the forty-third annual meeting of the American Public Health Association and the fifteenth annual conference of sanitary officers of the State of New York at Rochester, N. Y., a symposium on the administrative control of infectious diseases was held on September 10, 1915, under the joint auspices of the Section of Public Health Officials and the ...
openaire   +3 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Impact of two-dose varicella vaccination in Guangzhou: An interrupted time-series study

Human Vaccines & Immunotherapeutics
In November 2017, Guangzhou implemented a self-paid two-dose varicella vaccination program. This study evaluated the program’s impact on varicella incidence trends across the general population and specific age groups. An interrupted time-series analysis
Huan Zhang, Yanhui Liu, Xing Ye, Lei Luo, Qing He   +4 more
doaj   +1 more source

Spicy food consumption is associated with abdominal obesity among Chinese Han population aged 30–79 years in the Sichuan Basin: a population-based cross-sectional study

BMC Public Health, 2022
Background Few animal experiments and volunteer-based intervention studies have showed a controversial effect of spicy foods on abdominal obesity. We aimed to examine the association between spicy food frequency, spicy flavor, and abdominal obesity among
Xianxian Yang, Wenge Tang, Deqiang Mao, Xiang Liu, Wen Qian, Yingxue Dai, Liling Chen, Xianbin Ding   +7 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Newly estimated disability weights for 196 health states in Hubei Province, China

Population Health Metrics
Background The disability weight (DW) reflects the severity of non-fatal outcomes and is an important parameter in calculating the burden of disease. However, the universality of the global, national, or subnational DWs remains controversial.
Mengge Zhou, Lan Zhang, Tianjing He, Shuzhen Zhu, Yumeng Tang, Qian Li, Miaoyan Shen, Jingju Pan   +7 more
doaj   +1 more source

Clinical characteristics and risk factors of Hepatitis E virus infection in Zhejiang Province: a multicenter case–control study

Frontiers in Public Health
IntroductionHepatitis E (HE), caused by the Hepatitis E virus (HEV), is a significant cause of acute viral hepatitis globally and a major public health concern, particularly in specific high-prevalence areas in China, which have diverse transmission ...
Yijuan Chen, Jian Gao, Wanwan Sun, Weiping Zhu, Pingping Wang, Xiaobin Ren, Yumeng Wu, Jianli Zhang, Ziping Miao   +8 more
doaj   +1 more source