Results 91 to 100 of about 3,097,640 (309)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Communicable Diseases Intelligence

Emerging Infectious Diseases, 1995
Helen Longbottom
doaj   +1 more source

The increasing prevalence of non-communicable diseases in low-middle income countries: the view from Malawi

, 2018
Matthew Gowshall,1,2 Simon D Taylor-Robinson1 1Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, London, UK; 2Barts and the London School of Medicine and Dentistry, London, UK Abstract: Non-communicable diseases ...
Taylor-Robinson SD, Gowshall M
core  

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Cohort profile of a longitudinal study on non-communicable diseases in employees in northwest Iran

Discover Public Health
Background The burden of non-communicable diseases (NCDs) is rising in Iran, contributing to many years of quality of life lost and premature deaths. Monitroing NCDs and related risk factors are crucial for prevention and resource allocation.
Manoochehr Mahram, Elahe Jafari, Amin Yazdani, Soudabeh Alatab, Atefeh Khoshkchali, Mohammad Amerzadeh, Abouzar Raeisvandi, Mehdi Osooli, Zahra Hosseinkhani   +8 more
doaj   +1 more source

Applied research in the Africa child survival initiative; lessons learned from the ACSI-CCCD Project : 1982-1993 [PDF]

"This report was supported ... by the Africa Bureau, Office of Operation and New Initiatives (ONI) and the Office of Analysis, Research and Technical Support (ARTS), United States Agency for International Development (A.I.D.) through the Africa Child ...

core  

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

The association of self-rated health with physical activity and demographic factors: a study in primary care from Northwest of Iran

BMC Primary Care
Background Self-rated health (SRH) is an international measure and indicator of mortality and morbidity that can be used as a mortality predictor in adulthood.
Hanieh Moradi, Abouzar Raeisvandi, Mahdie Bahrami, Mohammad Amerzadeh, Mozhgan Abbasi, Zahra Hosseinkhani, Mehdi Osooli   +6 more
doaj   +1 more source

Factors associated with communicable diseases, non-communicable diseases and external causes of adult deaths in northern Ethiopia, from September 2009 to March 2013 (n = 723).

, 2014
COD-Crude Odds Ratio, AOR-Adjusted Odds Ratio.Factors associated with communicable diseases, non-communicable diseases and external causes of adult deaths in northern Ethiopia, from September 2009 to March 2013 (n = 723).
Alemseged Aregay (625725), Yohannes Adama Melaku (554023), Semaw Ferede Abera (625726), Gordon Alexander Zello (625728), Fisaha Haile Tesfay (625723), Loko Abreha (625727), Berhe Weldearegawi Sahle (625722), Afework Mulugeta Bezabih (625724)   +7 more
core   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source