Results 81 to 90 of about 718,732 (310)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Study protocol for a cluster-randomized controlled trial of an NCD access to medicines initative: Evaluation of Novartis Access in Kenya [PDF]

, 2016
INTRODUCTION: Novartis recently launched Novartis Access, an initiative to provide a basket of reduced price medicines for non-communicable diseases (NCDs) to be sold through the public and private nonprofit sectors in programme countries.
Ashigbie, Paul G., Laing, Richard, Onyango, Monica A., Rockers, Peter C., Vian, Taryn, Wirtz, Veronika J.   +5 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, Volume 20, Issue 6, Page 1612-1625, June 2026.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Candida glabrata chorioamnionitis following IVF pregnancy

IDCases
Fungal chorioamnionitis is a rare but potentially life-threatening complication of pregnancy with significant maternal and fetal consequences. We describe a severe case of Candida glabrata chorioamnionitis in a 19-week twin pregnancy conceived through in
Junais Koleri, Hani Ghassan Hamad, Fatma Ben Abid, Sreethish Sasi, Ajithkumar V. Ittaman, Muna AlMaslamani   +5 more
doaj   +1 more source

Can Law Improve Prevention and Treatment of Cancer? [PDF]

, 2011
The December 2011 issue of Public Health (the Journal of the Royal Society for Public Health) contains a symposium entitled: Legislate, Regulate, Litigate? Legal approaches to the prevention and treatment of cancer.
Gostin, Lawrence O., Magnusson, Roger, Studdert, David   +2 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A rare case of concurrent longitudinally extensive myelitis and retinal vein occlusion

IDCases
Neurosyphilis can affect multiple organ systems, but simultaneous involvement of the spinal cord and retinal vasculature is exceedingly rare. We report a 36-year-old man presenting first with unilateral branch retinal vein occlusion (BRVO) and, two weeks
Junais Koleri, Musaed Saad A. Al Samawi, Hasan Syed Ahmedullah, Sreethish Sasi, Ajithkumar V. Ittaman, Muna Al Maslamani   +5 more
doaj   +1 more source

Recurrent nasopharyngeal rhinosporidiosis: Case report from Qatar and review of the literature

IDCases, 2020
Rhinosporidiosis is a chronic granulomatous infectious disease that predominantly affects the mucosal membranes of the nose and nasopharynx. The disease is caused by Rhinosporidium seeberi, an eukaryotic pathogen with distinct geographical distribution ...
Gawahir M. Ali, Wael Goravey, Samir A. Al Hyassat, Mahir Petkar, Muna A. Al Maslamani, Hamad Abdel Hadi   +5 more
doaj   +1 more source

Promotion of access to essential medicines for Non-Communicable Diseases: Practical implications of the UN Political Declaration [PDF]

, 2013
Access to medicines and vaccines to prevent and treat non-communicable diseases (NCDs) is unacceptably low worldwide. In the 2011 UN political declaration on the prevention and control of NCDs, heads of government made several commitments related to ...
Abdraimova, Alleyne, Atun, Barrington, Bigdeli, Cameron, Cameron, Cameron, Caudron, Chaudhuri, Colombo, Di Cesare, Downing, Faith N Mwangi-Powell, Ford, Ford, Frenk, Frost, Gale, Gilks, Goroff, Hans V Hogerzeil, Hardon, Heath, Hogerzeil, Hogerzeil, Jonathan Liberman, Kanavos, Kishore, Laing, Liberman, Lim, Lonn, Lu, Luiz, Marquez, Maxmen, Mills, Moodie, Moon, Outterson, Panchagnula, Perehudoff, Quick, Rachel Kiddell-Monroe, Reddy, Roderick, Sakthi Selvaraj, Sandeep P Kishore, Sanne, Smith, Szabo, Tido von Schoen-Angerer, Twagirumukiza, Twagirumukiza, Veronika J Wirtz, Wagner, Wald, Waning, Yusuf, ‘t Hoen   +60 more
core   +3 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1643-1660, June 2026.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source