Results 101 to 110 of about 9,469,626 (339)

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

The UK's Global Health Respiratory Network: Improving respiratory health of the world's poorest through research collaborations. [PDF]

, 2019
Respiratory disorders are responsible for considerable morbidity, health care utilisation, societal costs and approximately one in five deaths worldwide [1-4].
Adab, P, Balharry, D, Barreto, ML, Bauld, L, Campbell, H, Cooper, P, Cruz, A, Davidson, FM, Dodd, P, Enocson, A, Fitch, N, Griffiths, C, Grigg, J, Heyderman, RS, Jordan, R, Katikireddi, SV, Kuo, S, Kwambana-Adams, B, Leyland, AH, Mortimer, K, Mosler, G, Obasi, A, Orme, M, Readshaw, A, Savio, M, Sheikh, A, Siddiqi, K, Sifaki-Pistolla, D, Singh, S, Squire, B, Tsiligianni, I, Williams, S   +31 more
core   +8 more sources

Environmental Endocrine-Disrupting Chemical Exposure: Role in Non-Communicable Diseases

Frontiers in Public Health, 2020
The exponential growth of pollutant discharges into the environment due to increasing industrial and agricultural activities is a rising threat for human health and a biggest concern for environmental health globally.
Manoj Kumar, D. Sarma, Swasti Shubham, M. Kumawat, V. Verma, Anil Prakash, R. Tiwari   +6 more
semanticscholar   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

Diabetes in Sub Saharan Africa 1999-2011: Epidemiology and Public Health Implications. A Systematic Review. [PDF]

, 2011
Diabetes prevalence is increasing globally, and Sub-Saharan Africa is no exception. With diverse health challenges, health authorities in Sub-Saharan Africa and international donors need robust data on the epidemiology and impact of diabetes in order to ...
Hall, Victoria, Henriksen, Ole, Lohse, Nicolai, Thomsen, Reimar W   +3 more
core   +2 more sources

Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence

Nutrients, 2020
Tocotrienol (T3) is a subfamily of vitamin E known for its wide array of medicinal properties. This review aimed to summarize the health benefits of T3, particularly in prevention or treatment of non-communicable diseases (NCDs), including cardiovascular,
S. Wong, Y. Kamisah, Norazlina Mohamed, N. Muhammad, Norliana Masbah, Nur Azlina Mohd Fahami, I. Mohamed, Ahmad Nazun Shuid, Qodriyah Haji Mohd Saad, Azman Abdullah, Nur-Vaizura Mohamad, Nurul 'Izzah Ibrahim, K. Pang, Yoke Yue Chow, B. K. S. Thong, Shaanthana Subramaniam, C. Chan, S. Ima-Nirwana, K. Chin   +18 more
semanticscholar   +1 more source

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Modelling prevention strategies in Public Health [PDF]

, 2015
Various schemes of prevention measures in public health are developed and analyzed on the basis of a general mathematical model. Features related to cost issues, including primary and secondary prevention interventions, differential survival experiences
Parisi V., SCHINAIA, Giuseppe
core  

Promotion of access to essential medicines for Non-Communicable Diseases: Practical implications of the UN Political Declaration [PDF]

, 2013
Access to medicines and vaccines to prevent and treat non-communicable diseases (NCDs) is unacceptably low worldwide. In the 2011 UN political declaration on the prevention and control of NCDs, heads of government made several commitments related to ...
Abdraimova, Alleyne, Atun, Barrington, Bigdeli, Cameron, Cameron, Cameron, Caudron, Chaudhuri, Colombo, Di Cesare, Downing, Faith N Mwangi-Powell, Ford, Ford, Frenk, Frost, Gale, Gilks, Goroff, Hans V Hogerzeil, Hardon, Heath, Hogerzeil, Hogerzeil, Jonathan Liberman, Kanavos, Kishore, Laing, Liberman, Lim, Lonn, Lu, Luiz, Marquez, Maxmen, Mills, Moodie, Moon, Outterson, Panchagnula, Perehudoff, Quick, Rachel Kiddell-Monroe, Reddy, Roderick, Sakthi Selvaraj, Sandeep P Kishore, Sanne, Smith, Szabo, Tido von Schoen-Angerer, Twagirumukiza, Twagirumukiza, Veronika J Wirtz, Wagner, Wald, Waning, Yusuf, ‘t Hoen   +60 more
core   +3 more sources

Ultra-Processed Food Consumption and Chronic Non-Communicable Diseases-Related Dietary Nutrient Profile in the UK (2008–2014)

Nutrients, 2018
We described the contribution of ultra-processed foods in the U.K. diet and its association with the overall dietary content of nutrients known to affect the risk of chronic non-communicable diseases (NCDs). Cross-sectional data from the U.K.
F. Rauber, Maria Laura da Costa Louzada, E. Steele, C. Millett, C. Monteiro, R. Levy   +5 more
semanticscholar   +1 more source