Results 81 to 90 of about 9,469,626 (339)
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Health in the sustainable development goals: ready for a paradigm shift? [PDF]
, 2015 The Millennium Development Goals (MDGs) galvanized attention, resources and accountability on a small number of health concerns of low- and middle-income countries with unprecedented results.
Buse, K, Hawkes, S
core +1 more source
FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source
The prevalence, communicability and co-occurrence of inverted hallucinations: an overlooked global public health concern [PDF]
, 2019 While scientific understanding concerning the role of biological pathogenic agents in the transmission of communicable diseases has increased markedly in recent decades, the possibility of a psychological pathogenic agent that underlies the transmission ...
Ducasse, Deborah +3 more
core +1 more source
Emerging challenges and health system capacity: the case of non- communicable diseases in Pakistan; a review [PDF]
, 2014 Background: Pakistan is facing double burden of disease and the contribution of mortality by non-communicable diseases has over numbered the communicable diseases.
Malik, Muhammad Ashar, Zafar, Mubashir
core +2 more sources
Mindfulness interventions reduce blood pressure in patients with non-communicable diseases: A systematic review and meta-analysis [PDF]
, 2020 Purpose Mindfulness based interventions (MBIs) are an emerging area of empirical study, not only in positive psychology, but also in clinical health care.
Abbott +39 more
core +1 more source
BMC Public Health, 2020 Addressing non-communicable disease (NCDs) is a global priority in the Sustainable Development Goals, especially for adolescents. However, existing literature on NCD burden, risk factors and determinants, and effective interventions and policies for ...
N. Akseer +10 more
semanticscholar +1 more source
A working model for cytoplasmic assembly of H/ACA snoRNPs
FEBS Letters, EarlyView.Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley +1 more source
Reframing non-communicable diseases [PDF]
The Lancet Global Health, 2017 Proposer de travailler sur les maladies chroniques non-infectieuses comme "maladies socialement transmises" ("socially transmitted conditions") prolonge un lieu commun partage depuis plusieurs decennies en epidemiologie sur le caractere plurifactoriel de ces maladies. Cela ne doit pas empecher de penser que les maladies infectieuses doivent aussi etre
Cavalin, Catherine, Lescoat, Alain
openaire +6 more sources
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source